肝移植术后混合型及播散型副球孢子菌病：病例报告
Mixed and disseminated paracoccidioidomycosis after liver transplantation: Case report.
作者信息
Sinkos Camila, Grillo Thais Gagno, Bonini Ana Clara Muraro, Cardoso Lucas Gonçalves, Watanabe Erika Mayumi, Cavalcante Ricardo de Souza, Silva Giovanni Faria, Yamashiro Fabio da Silva, Romeiro Fernando Gomes, Lima Talles Bazeia
机构信息
Department of Internal Medicine, Gastroenterology Division - São Paulo State University (UNESP), Botucatu Medical School, Rubião Júnior S/N, 18618-970, São Paulo, Brazil.
Department of Internal Medicine, Hematology Division - São Paulo State University (UNESP), Botucatu Medical School, Rubião Júnior S/N, 18618-970, São Paulo, Brazil.
出版信息
Med Mycol Case Rep. 2021 Feb 23;32:25-29. doi: 10.1016/j.mmcr.2021.02.004. eCollection 2021 Jun.
Paracoccidioidomycosis (PCM) is a systemic granulomatous fungal infection rarely associated with solid organ transplantation. We report the second case of PCM in an adult after liver transplantation. A 47-year-old woman who had undergone liver transplantation was hospitalized for flu-like symptoms and multiple erythematous ulcerated skin papules. There was lymphadenopathy, pulmonary compromise, and quickly progression to septic shock. PCM was confirmed by skin biopsy and serologic tests, and a satisfactory response to amphotericin B was achieved.
副球孢子菌病（PCM）是一种全身性肉芽肿性真菌感染，很少与实体器官移植相关。我们报告了肝移植术后成人发生PCM的第二例病例。一名接受肝移植的47岁女性因流感样症状和多处红斑性溃疡皮肤丘疹入院。存在淋巴结病、肺部损害，并迅速进展为感染性休克。通过皮肤活检和血清学检查确诊为PCM，且对两性霉素B治疗反应良好。
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