正在减少吸烟量的吸烟者的代谢参数。

Metabolic parameters in smokers undergoing smoking reduction.

作者信息

Hsia Stanley H, Nisis Monica L, Lee Martin L, Goldstein Candice, Friedman Theodore C

机构信息

Division of Endocrinology, Metabolism and Molecular Medicine, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, 1731 East 120 Street, Los Angeles, CA 90059, USA.

David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA.

出版信息

J Clin Transl Endocrinol. 2021 Jan 23;23:100249. doi: 10.1016/j.jcte.2021.100249. eCollection 2021 Mar.

DOI:10.1016/j.jcte.2021.100249

PMID:33717989

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7933731/

Abstract

INTRODUCTION

Few human studies have explored the mechanisms of smoking-induced insulin resistance. : To prospectively examine the metabolic changes of smoking reduction.

METHODS

Cigarette smokers (n = 22; ½-2 packs per day) were enrolled in a smoking reduction program (counseling plus bupropion × 8 weeks; Phase I) followed by monitoring only (no counseling or bupropion × 16 weeks; Phase II). We serially measured exhaled carbon monoxide (CO) and urine nicotine metabolites; fat distribution, and metabolic parameters by hyperinsulinemic clamps including hepatic glucose output (HGO) and indirect calorimetry, adjusted for total caloric intake and expenditure.

RESULTS

CO and nicotine metabolite levels fell with smoking reduction during Phase I (all p < 0.05), without any further changes through Phase II. Central-to-peripheral fat ratio increased during Phase I, but then fell during Phase II (all p < 0.05). Over 24 weeks, basal HGO fell (p = 0.02); and falling CO and nicotine metabolite levels correlated inversely with changes in glucose oxidation, and directly with changes in weight (all p < 0.05).

CONCLUSIONS

Smoking reduction produced a transient worsening of central fat redistribution followed by a more significant improvement; along with other net beneficial metabolic effects.

摘要

引言

很少有人类研究探索吸烟诱导胰岛素抵抗的机制。目的是前瞻性地研究减少吸烟后的代谢变化。

方法

招募每日吸烟量为半包至2包的吸烟者（n = 22）参加一个减少吸烟计划（咨询加安非他酮，为期8周；第一阶段），随后仅进行监测（无咨询或安非他酮，为期16周；第二阶段）。我们连续测量呼出一氧化碳（CO）和尿液尼古丁代谢产物；通过高胰岛素钳夹技术测量脂肪分布和代谢参数，包括肝脏葡萄糖输出（HGO）和间接测热法，并根据总热量摄入和消耗进行调整。

结果

在第一阶段，随着吸烟量减少，CO和尼古丁代谢产物水平下降（所有p < 0.05），在第二阶段没有进一步变化。中心与外周脂肪比率在第一阶段增加，但在第二阶段下降（所有p < 0.05）。在24周内，基础HGO下降（p = 0.02）；CO和尼古丁代谢产物水平的下降与葡萄糖氧化的变化呈负相关，与体重变化呈正相关（所有p < 0.05）。