尼古丁和香烟烟雾的内分泌影响。
The endocrine effects of nicotine and cigarette smoke.
机构信息
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.
出版信息
Trends Endocrinol Metab. 2012 Jul;23(7):334-42. doi: 10.1016/j.tem.2012.03.006. Epub 2012 May 2.
Abstract
With a current prevalence of approximately 20%, smoking continues to impact negatively upon health. Tobacco or nicotine use influences the endocrine system, with important clinical implications. In this review we critically evaluate the literature concerning the impact of nicotine as well as tobacco use on several parameters of the endocrine system and on glucose and lipid homeostasis. Emphasis is on the effect of smoking on diabetes mellitus and obesity and the consequences of smoking cessation on these disorders. Understanding the effects of nicotine and cigarettes on the endocrine system and how these changes contribute to the pathogenesis of various endocrine diseases will allow for targeted therapies and more effective approaches for smoking cessation.
摘要
目前，吸烟的流行率约为 20%，但其仍对健康产生负面影响。烟草或尼古丁的使用会影响内分泌系统，具有重要的临床意义。在这篇综述中，我们批判性地评估了有关尼古丁和烟草使用对内分泌系统的几个参数以及葡萄糖和脂质稳态的影响的文献。重点是吸烟对糖尿病和肥胖的影响，以及戒烟对这些疾病的后果。了解尼古丁和香烟对内分泌系统的影响，以及这些变化如何导致各种内分泌疾病的发病机制，将有助于针对这些疾病的治疗方法，并为戒烟提供更有效的方法。
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