Lucas-Cava Vanesa, Sánchez-Margallo Francisco Miguel, García-Martínez Virginio, López-Sánchez Carmen, Báez-Díaz Claudia, Dávila-Gómez Luis, Lima-Rodríguez Juan Rafael, Sun Fei
Endoluminal Therapy and Diagnosis Unit, Jesús Usón Minimally Invasive Surgery Centre, Cáceres, Spain.
Scientific Director, Jesús Usón Minimally Invasive Surgery Centre, Cáceres, Spain.
Transl Androl Urol. 2021 Feb;10(2):869-878. doi: 10.21037/tau-20-1320.
The purpose was to assess the association between prostate infarction and prostate volume (PV) reduction after prostatic artery embolization (PAE) and define the best time point in detection of prostate infarction.
Ten male beagles (3.5-6.4 years) with spontaneous benign prostatic hyperplasia (BPH) underwent PAE. Magnetic resonance image (MRI) was conducted immediately before and 1 week, 2 weeks and 1 month after PAE to document prostate infarcts and measure PV. The sum of infarct areas (SUMIA) was measured and calculated using OsiriX software. Spearman's rank correlation was used to estimate the relationship of PV reduction rate with infarction percentage and SUMIA reduction.
In comparison with baseline data, significant PV reduction (P<0.001) occurred at 2 weeks and continued to decrease substantially (P=0.004) from 2 weeks to 1 month after PAE. In the same fashion, significant decrease in both SUMIA and infarction percentage was observed from 1 to 2 weeks (P=0.002), and subsequently to 1 month (P=0.039 and P=0.016, respectively). Spearman's rank correlation test demonstrated infarction percentage at 1 week had a stronger correlation (r=0.880, P=0.001) with PV reduction rate at 1 month than infarction percentage at 2 weeks (r=0.733, P=0.016). PV reduction rate had a significant correlation with decrease in SUMIA (r=0.854, P=0.002) at 1 month after PAE.
One week after PAE is an ideal time point to evaluate prostate infarction. Prostate infarction percentage at 1 week is a good predictor for prostate shrinkage at 1 month after PAE.
目的是评估前列腺动脉栓塞术（PAE）后前列腺梗死与前列腺体积（PV）缩小之间的关联，并确定检测前列腺梗死的最佳时间点。
对10只患有自发性良性前列腺增生（BPH）的雄性比格犬（3.5 - 6.4岁）进行PAE。在PAE前以及PAE后1周、2周和1个月立即进行磁共振成像（MRI），以记录前列腺梗死情况并测量PV。使用OsiriX软件测量并计算梗死面积总和（SUMIA）。采用Spearman等级相关分析来评估PV缩小率与梗死百分比及SUMIA缩小之间的关系。
与基线数据相比，PAE后2周时PV显著缩小（P<0.001），且从2周持续至1个月时大幅下降（P = 0.004）。同样，SUMIA和梗死百分比在1至2周时显著下降（P = 0.002），随后至1个月时也显著下降（分别为P = 0.039和P = 0.016）。Spearman等级相关检验表明，1周时的梗死百分比与1个月时的PV缩小率之间的相关性（r = 0.880，P = 0.001）比2周时的梗死百分比（r = 0.733，P = 0.016）更强。PAE后1个月时，PV缩小率与SUMIA的下降显著相关（r = 0.854，P = 0.002）。
PAE后1周是评估前列腺梗死的理想时间点。1周时的前列腺梗死百分比是PAE后1个月前列腺缩小的良好预测指标。
