Zhao Yan, Zhu Yanting, Wang Haiqing, Ji Chao
Department of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Front Oncol. 2021 Feb 26;11:650974. doi: 10.3389/fonc.2021.650974. eCollection 2021.
Few studies have evaluated acitretin as a primary treatment for cutaneous squamous cell carcinoma (CSCC). We report, for the first time, three cases of CSCC successfully treated with acitretin and clarithromycin. A literature review on this subject was also was performed. This case report included three patients with CSCC treated with acitretin and clarithromycin at the First Affiliated Hospital of Fujian Medical University (2008-2019). Patient 1 (83-year-old woman, ulcerated mass on the left cheek), patient 2 (97-year-old woman, painful mass on the left cheek) and patient 3 (76-year-old woman, large mass on the right ankle) received 8, 6, and 30 courses of combination therapy. All patients tolerated the adverse effects (pseudotumor cerebri and mucocutaneous dryness) and achieved complete regression within 6 months. Patients 1, 2, and 3 have not experienced recurrence during a 10-, 3-, and 6-year follow-up. Acitretin has limited efficacy as a monotherapy for CSCC. Our experience indicates that combination therapy with acitretin and clarithromycin may be an effective and well-tolerated treatment for unresectable CSCC.
很少有研究评估阿维A作为皮肤鳞状细胞癌（CSCC）的主要治疗方法。我们首次报告了3例经阿维A和克拉霉素成功治疗的CSCC病例。我们还对该主题进行了文献综述。本病例报告包括在福建医科大学附属第一医院（2008 - 2019年）接受阿维A和克拉霉素治疗的3例CSCC患者。患者1（83岁女性，左脸颊溃疡肿物）、患者2（97岁女性，左脸颊疼痛肿物）和患者3（76岁女性，右踝部巨大肿物）分别接受了8、6和30个疗程的联合治疗。所有患者均耐受不良反应（假性脑瘤和皮肤黏膜干燥），并在6个月内实现完全消退。患者1、2和3在10年、3年和6年的随访中均未出现复发。阿维A作为CSCC的单一疗法疗效有限。我们的经验表明，阿维A和克拉霉素联合治疗可能是不可切除CSCC的一种有效且耐受性良好的治疗方法。
