Hua Yanan, Song Jinlian, Peng Cuixiu, Wang Runze, Ma Zhongliang, Zhang Jinyu, Zhang Zheng, Li Ning, Hou Lin
Department of Neurobiology, Basic Medical College, Qingdao University, Qingdao, China.
Department of Laboratory, Women and Children's Hospital of Qingdao, Qingdao, China.
Front Cell Dev Biol. 2021 Feb 25;9:620925. doi: 10.3389/fcell.2021.620925. eCollection 2021.
A regulator of ribosome synthesis 1 (RRS1) was discovered in yeast and is mainly localized in the nucleolus and endoplasmic reticulum. It regulates ribosomal protein, RNA biosynthesis, and protein secretion and is closely involved in cellular senescence, cell cycle regulation, transcription, translation, oncogenic transformation etc., Mutations in the RRS1 gene are associated with the occurrence and development of Huntington's disease and cancer, and overexpression of RRS1 promotes tumor growth and metastasis. In this review, the structure, function, and mechanisms of RRS1 in various diseases are discussed.
核糖体合成调节因子1（RRS1）在酵母中被发现，主要定位于核仁与内质网。它调节核糖体蛋白、RNA生物合成以及蛋白质分泌，并紧密参与细胞衰老、细胞周期调控、转录、翻译、致癌转化等过程。RRS1基因突变与亨廷顿舞蹈病和癌症的发生发展相关，RRS1的过表达促进肿瘤生长和转移。在本综述中，将讨论RRS1在各种疾病中的结构、功能及机制。
