Kılınç Hekimsoy Hilal, Şekeroğlu Ali Mehmet, Koçer Ali Mert, Hekimsoy Vedat, Akdoğan Ali
Ophthalmologist, Department of Ophthalmology, Ulucanlar Eye Training and Research Hospital, 06240 Ankara, Turkey.
Department of Ophthalmology, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
Ther Adv Ophthalmol. 2021 Feb 27;13:2515841421995387. doi: 10.1177/2515841421995387. eCollection 2021 Jan-Dec.
To investigate the optical coherence tomography angiography (OCTA) parameters of the optic nerve head and peripapillary retina and to assess macular and peripapillary retinal nerve fiber layer (RNFL) thickness by using spectral-domain optical coherence tomography (SD-OCT) in patients with limited scleroderma and to compare these results with those of healthy control subjects.
42 patients with a confirmed diagnosis of limited scleroderma and 32 age- and sex-matched healthy control subjects were included in the study. OCTA was performed for the radial peripapillary capillary plexus (RPCP) whole image, inside disc, and peripapillary vessel densities in all participants with XR Avanti AngioVue OCTA (Optovue, Fremont, California, USA). OCT images were obtained with Spectralis OCT with eye-tracking dual-beam technology (Heidelberg Engineering GmbH, Heidelberg, Germany), and peripapillary RNFL thickness was evaluated with circle program. The data from the right eyes of all participants were used for statistical analysis.
No significant difference was found between the radial RPCP whole image, inside disc, and peripapillary vessel density values or the RNFL parameters of the scleroderma patients when compared with the controls ( > 0.05 for all).
Decreased peripapillary vessel density on OCTA, which can be an early sign of glaucoma, could not be observed in scleroderma patients in this study. However, further long-term studies are still needed to identify glaucoma tendency in patients with scleroderma before clinically detectable glaucoma.
研究局限性硬皮病患者视神经乳头和视乳头周围视网膜的光学相干断层扫描血管造影（OCTA）参数，并使用光谱域光学相干断层扫描（SD - OCT）评估黄斑和视乳头周围视网膜神经纤维层（RNFL）厚度，同时将这些结果与健康对照受试者的结果进行比较。
本研究纳入42例确诊为局限性硬皮病的患者和32例年龄及性别匹配的健康对照受试者。所有参与者均使用XR Avanti AngioVue OCTA（美国加利福尼亚州弗里蒙特市Optovue公司）对视乳头周围放射状毛细血管丛（RPCP）全图像、视盘内以及视乳头周围血管密度进行OCTA检查。使用带有眼动追踪双光束技术的Spectralis OCT（德国海德堡海德堡工程有限公司）获取OCT图像，并使用圆周程序对视乳头周围RNFL厚度进行评估。所有参与者右眼的数据用于统计分析。
与对照组相比，硬皮病患者的视乳头周围放射状RPCP全图像、视盘内以及视乳头周围血管密度值或RNFL参数均无显著差异（所有P值均>0.05）。
在本研究的硬皮病患者中未观察到OCTA上视乳头周围血管密度降低，而视乳头周围血管密度降低可能是青光眼的早期迹象。然而，仍需要进一步的长期研究来确定硬皮病患者在临床可检测到青光眼之前的青光眼倾向。
