State Key Laboratory of Ophthalmology, Department of Glaucoma, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Curr Eye Res. 2020 May;45(5):629-635. doi: 10.1080/02713683.2019.1676912. Epub 2019 Oct 14.
: To evaluate macular and radial peripapillary capillary vessel densities (RPC VD) across normal, pre-perimetric (PPG), and early perimetric primary open-angle glaucoma (EG) using optical coherence tomography angiography (OCTA).: Forty-four PPG eyes, 42 EG eyes, and 41 normal eyes were consecutively enrolled. All subjects underwent visual field, OCT, and OCTA examinations. Macular vessel densities were measured in the superficial layer. RPC VD was measured within a 750-μm-wide elliptical annulus extending outward from disc boundary. Diagnostic ability was evaluated with area under the receiver operating curve.: Parafoveal vessel densities (ParaVDs) in the PPG group were comparable to the normal group ( > .05), except for temporal quadrant ( = .044), while perifoveal vessel densities (PeriVD) were lower in the PPG group ( < .05). ParaVD and PeriVD were lower in the EG group compared with the normal group ( < .001). Superior-temporal and inferior-temporal retinal nerve fiber layers (RNFLs) were significantly decreased in the EG group compared with the PPG group ( < .05), while only inferior-temporal RPC VD was lower in the EG group ( < .05). RPC VD was comparable to RNFL and ganglion cell complex (GCC) in the diagnosis of PPG ( > .05). Macular whole image vessel density and PeriVD were comparable to RPC VD, RNFL, and GCC in diagnosing EG ( > .05).: In early primary open-angle glaucoma, significant microvascular damage was present in both macular and peripapillary areas. The damage of macular microvasculature was more prominent in the peripheral area. Vessel density parameters showed promising diagnostic ability in early glaucoma.: POAG = primary open-angle glaucoma; RGC = retinal ganglion cell; OCTA = optical coherence tomography angiography; RNFL = retinal nerve fiber layer; PPG = pre-perimetric primary open-angle glaucoma; EG = early perimetric primary open-angle glaucoma; IOP = intraocular pressure; PSD = pattern standard deviation; MD = mean deviation; GCC = ganglion cell complex; SBP = systolic blood pressure; DBP = diastolic blood pressure; MAP = mean arterial pressure; MOPP = mean ocular perfusion pressure; wiVD = whole image vessel density; ParaVD = parafoveal vessel density; PeriVD = perifoveal vessel density; RPC VD = radial peripapillary capillary vessel density; AUC = area under the receiver operating curve.
利用光相干断层扫描血管造影术（OCTA）评估正常、预视野（PPG）和早期视野原发性开角型青光眼（EG）的黄斑和放射状视盘周围毛细血管血管密度（RPC VD）。连续纳入 44 只 PPG 眼、42 只 EG 眼和 41 只正常眼。所有受试者均行视野、OCT 和 OCTA 检查。在浅层测量黄斑血管密度。在从视盘边界向外延伸的 750μm 宽椭圆形环内测量 RPC VD。使用受试者工作特征曲线下的面积评估诊断能力。PPG 组的旁中心血管密度（ParaVD）与正常组相当（>.05），仅颞象限（=.044）除外，而 PPG 组的中心凹下血管密度（PeriVD）较低（<.05）。与正常组相比，EG 组的 ParaVD 和 PeriVD 均较低（<.001）。与 PPG 组相比，EG 组的上颞和下颞视网膜神经纤维层（RNFL）明显变薄（<.05），而仅下颞 RPC VD 较低（<.05）。RPC VD 在 PPG 的诊断中与 RNFL 和节细胞复合体（GCC）相当（>.05）。黄斑全像血管密度和 PeriVD 在 EG 的诊断中与 RPC VD、RNFL 和 GCC 相当（>.05）。在原发性开角型青光眼早期，黄斑和视盘周围区域均存在明显的微血管损伤。黄斑微血管损伤在外周区域更为明显。血管密度参数在早期青光眼的诊断中具有良好的诊断能力。POAG = 原发性开角型青光眼；RGC = 视网膜神经节细胞；OCTA = 光相干断层扫描血管造影术；RNFL = 视网膜神经纤维层；PPG = 预视野原发性开角型青光眼；EG = 早期视野原发性开角型青光眼；IOP = 眼内压；PSD = 模式标准差；MD = 平均偏差；GCC = 节细胞复合体；SBP = 收缩压；DBP = 舒张压；MAP = 平均动脉压；MOPP = 平均眼灌注压；wiVD = 全像血管密度；ParaVD = 旁中心血管密度；PeriVD = 中心凹下血管密度；RPC VD = 放射状视盘周围毛细血管血管密度；AUC = 受试者工作特征曲线下的面积。
