Nachshon Liat, Schwartz Naama, Goldberg Michael R, Schon Yossi, Cheryomukhin Michael, Katz Yitzhak, Elizur Arnon
Allergy clinic, Israel Defense Forces Medical Corps, Israel.
Institute of Allergy, Immunology and Pediatric Pulmonology, Shamir Medical Center, Zerifin, Israel.
EClinicalMedicine. 2021 Feb 26;33:100766. doi: 10.1016/j.eclinm.2021.100766. eCollection 2021 Mar.
Many patients with self-reported food allergy are not allergic but suffer from similar burdens. We aimed to characterize young adults with misconceived food allergy.
A cross-sectional study of individuals ( = 12,592) aged 17-18 years, recruited to the Israel Defense Forces (IDF) at a single urban-area recruitment center over a six month-period. All participants underwent a comprehensive medical and psychological evaluation. Cognitive tests were performed and a Combined Intellectual-Education score assigned. Participants who reported food elimination due to allergy were skin-tested and underwent oral food challenges, when indicated. The characteristics, psychological evaluation and cognitive tests of individuals with no reported food allergy ( = 12,444), misconceived food allergy ( = 64) and true food allergy ( = 84) were compared.
The prevalence of atopic co-morbidities was higher in recruits reporting compared to those not reporting food allergy while the rate of other co-morbidities was comparable. Anxiety disorder was diagnosed significantly more in individuals who reported food allergy (4·1%) compared to those who did not (1·7%) ( = 0·04). Further analysis revealed that this diagnosis was concentrated in individuals with misconceived (8/64, 12·5%) compared to true food allergy (2/84, 2·4%), ( = 0·02). Patients with misconceived food allergy were mostly of female sex, had lower Combined Intellectual-Education scores compared to patients with true ( = 0·001) and no reported food allergy ( = 0·01), and required the longest mean evaluation time (147·6 ± 109·4 days).
Patients with misconceived food allergy have higher rates of anxiety disorder and are often from a lower educational level and of female sex. Medical and educational attention is required to improve care of this specific population.
The research reported in this publication was supported by the Israel Defense Forces (IDF) Medical Corps and Directorate of Defense Research & Development, Israeli Ministry of Defense (IMOD DDR&D).
许多自述有食物过敏的患者并非过敏，而是承受着类似的负担。我们旨在对患有误解性食物过敏的年轻人进行特征描述。
对在一个城市征兵中心为期六个月招募的12592名17 - 18岁的个体进行横断面研究。所有参与者都接受了全面的医学和心理评估。进行了认知测试并给出了综合智力 - 教育得分。报告因过敏而进行食物排除的参与者进行了皮肤测试，并在必要时接受了口服食物激发试验。比较了未报告食物过敏（12444人）、误解性食物过敏（64人）和真正食物过敏（84人）个体的特征、心理评估和认知测试结果。
与未报告食物过敏的新兵相比，报告有食物过敏的新兵特应性合并症的患病率更高，而其他合并症的发生率相当。报告有食物过敏的个体中焦虑症的诊断率（4.1%）显著高于未报告者（1.7%）（P = 0.04）。进一步分析显示，与真正食物过敏者（2/84，2.4%）相比，这种诊断集中在误解性食物过敏者中（8/64，12.5%），（P = 0.02）。误解性食物过敏患者大多为女性，与真正食物过敏患者（P = 0.001）和未报告食物过敏患者（P = 0.01）相比，其综合智力 - 教育得分较低，并且平均评估时间最长（147.6 ± 109.4天）。
误解性食物过敏患者焦虑症的发生率较高，且往往教育水平较低且为女性。需要医疗和教育方面的关注来改善对这一特定人群的护理。
本出版物中报告的研究得到了以色列国防军医疗队以及以色列国防部国防研究与发展局（IMOD DDR&D）的支持。
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