Division of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Department of Laboratory Oncology, Dr. BRA Institute Research Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
Pediatr Blood Cancer. 2021 Jun;68(6):e29005. doi: 10.1002/pbc.29005. Epub 2021 Mar 15.
Information regarding the novel coronavirus disease (COVID-19) in pediatric oncology is limited. We conducted a systematic review of the available published literature on children with cancer affected by COVID-19. The last date of the study search was October 20, 2020, and 33 studies comprising 226 children were included for the final analysis. Data were extracted in a predefined data collection form, and the variables were extracted and analyzed. Patients with hematological malignancies were more in number. Males and children on intensive treatment were more frequently affected. Fever was the commonest symptom. The disease was asymptomatic/mild in 48% and severe in 9.6%. Consolidation, peribronchial cuffing, and consolidation with ground glass opacities were the common imaging findings. Hydroxychloroquine was the most frequently used drug for COVID-19. About 10% of children required intensive care, and about 32% had oxygen requirements. The percentage of children who died due to COVID-19 was 4.9%. The severity, morbidity, and mortality of COVID-19 in pediatric oncology were more compared to the general pediatric population. This information can help in risk stratification for the management of COVID-19.
关于儿童肿瘤中新型冠状病毒疾病（COVID-19）的信息有限。我们对已发表的关于癌症儿童感染 COVID-19 的可用文献进行了系统回顾。研究搜索的最后日期为 2020 年 10 月 20 日，共有 33 项研究包括 226 名儿童纳入最终分析。数据从预定义的数据收集表中提取，提取并分析变量。血液系统恶性肿瘤患者较多。男性和接受强化治疗的儿童更常受到影响。发烧是最常见的症状。48%的患者无症状/轻度，9.6%的患者严重。常见的影像学表现为肺间质炎症、支气管周围袖口征和实变伴磨玻璃影。羟氯喹是治疗 COVID-19 最常用的药物。约 10%的儿童需要重症监护，约 32%的儿童需要吸氧。COVID-19 导致儿童死亡的比例为 4.9%。儿童肿瘤中 COVID-19 的严重程度、发病率和死亡率均高于一般儿科人群。这些信息有助于 COVID-19 管理的风险分层。
