[周围神经错配再生的研究进展]
[Research progress of peripheral nerve mismatch regeneration].
作者信息
Wang Kunliang, Qin Bengang
机构信息
Department of Microsurgery, Orthopaedic Trauma and Hand Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou Guangdong, 510080, P.R.China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2021 Mar 15;35(3):387-391. doi: 10.7507/1002-1892.202008085.
OBJECTIVE
To review the research progress of peripheral nerve mismatch regeneration, and to provide reference for its related basic research and clinical treatment.
METHODS
The pathophysiology of peripheral nerve after injury, several main factors affecting the mismatch regeneration of peripheral nerve, and the fate of axon after mismatch regeneration were summarized by referring to the relevant literature at home and abroad in recent years.
RESULTS
Distal pathways and target organs can selectively affect the mismatch regeneration of peripheral nerves; different phenotypes of Schwann cells have different effects on the mismatch regeneration of peripheral nerves; studying the mechanism of action of exosomes from different Schwann cells on different types of axons can provide a new direction for solving the mismatch regeneration of peripheral nerves.
CONCLUSION
Peripheral nerve mismatch regeneration is affected by various factors. However, the specific mechanism and characteristics of these factors remain to be further studied.
目的
综述周围神经错配再生的研究进展，为其相关基础研究及临床治疗提供参考。
方法
通过查阅近年来国内外相关文献，总结周围神经损伤后的病理生理学、影响周围神经错配再生的几个主要因素以及错配再生后轴突的命运。
结果
远端通路和靶器官可选择性影响周围神经的错配再生；雪旺细胞的不同表型对周围神经的错配再生有不同影响；研究不同雪旺细胞来源的外泌体对不同类型轴突的作用机制可为解决周围神经错配再生提供新方向。
结论
周围神经错配再生受多种因素影响。然而，这些因素的具体机制和特点仍有待进一步研究。
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