Chen Zhen, Zhang Guang-Bo, Zhou Di, Cheng Xiang, Zhu Ling-Ling, Fan Ming, Wang Du-Ming, Zhao Yong-Qi
Zhejiang Sci-Tech University, Hangzhou 310018.
Center For Brain Disorders Research, Capotal Medical University and Beijing Institute Of Brain Disorders, Beijing 100069.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2020 Nov;36(6):556-561. doi: 10.12047/j.cjap.5978.2020.117.
To investigate the effects of acute high altitude hypoxia on EEG power in different emotional states. This study was two-factor within-subject design (2 levels of oxygen environment ×4 levels of emotion type). Twelve male subjects aged between 20 and 25 years old were induced to produce four different types of emotions by emotional picture evoked paradigm: low valence and low arousal(LVLA), high valence and low arousal(HVLA), low valence and high arousal(LVHA), high valence and high arousal(HVHA). Brain Products 32 was used to collect EEG signals under different emotional states. The next day, a constant depressed oxygen chamber was used to simulate a 4 300 m plateau hypoxia environment, and the same group of subjects used the same experimental paradigm to collect EEG signals 10h after hypoxia. The collected EEG signals were analyzed by power spectrum (FFT), and the five frequency bands (Delta, Theta, Alpha, beta, gamma) of the frontal lobe (F3\Fz\F4) were analyzed by variance analysis of two-factor repeated measurements. FFT analysis found that before and after acute hypoxia, the whole brain distribution of alpha wave in four emotional states was mainly concentrated in frontal and parietal leaves; the distribution of alpha wave in the whole brain was the least in relaxed emotional state. The results of the two-factor repeated measurement ANOVA showed that: ①the power of delta\ beta band was significantly affected by the oxygen environment(＜0.05), and the power was enhanced under hypoxia. ②The power index of theta\ alpha band showed a significant interaction between the oxygen environment and emotional types(＜0.05). Except for the HVLA emotional state, the power of theta alpha band was significantly enhanced under hypoxia. ③ The two factors had no significant influence on the gamma band(＞0.05). Under the four kinds of emotional states, the difference of the influence of oxygen environment on brain activity was mainly in the frontal lobe, parietal lobe and part of temporal lobe. Of the four types of emotions, the oxygen environment had the least significant effect on brain activity in HVLA emotional states, while the rest showed significant differences.
为研究急性高原低氧对不同情绪状态下脑电功率的影响。本研究采用两因素被试内设计（氧环境2水平×情绪类型4水平）。选取12名年龄在20至25岁之间的男性被试，通过情绪图片诱发范式诱导其产生四种不同类型的情绪：低效价低唤醒（LVLA）、高效价低唤醒（HVLA）、低 效价高唤醒（LVHA）、高效价高唤醒（HVHA）。采用Brain Products 32在不同情绪状态下采集脑电信号。次日，使用恒压低氧舱模拟4300米高原低氧环境，同一组被试在低氧10小时后采用相同实验范式采集脑电信号。对采集到的脑电信号进行功率谱（FFT）分析，采用两因素重复测量方差分析对额叶（F3\Fz\F4）的五个频段（δ、θ、α、β、γ）进行分析。FFT分析发现，急性低氧前后，四种情绪状态下α波的全脑分布主要集中在额叶和顶叶；在放松情绪状态下，全脑α波分布最少。两因素重复测量方差分析结果显示：①δ\β频段功率受氧环境影响显著（＜0.05），低氧状态下功率增强。②θ\α频段功率指数在氧环境与情绪类型之间存在显著交互作用（＜0.05）。除HVLA情绪状态外，低氧状态下θ\α频段功率显著增强。③两因素对γ频段无显著影响（＞0.05）。在四种情绪状态下，氧环境对脑活动影响的差异主要集中在额叶、顶叶及部分颞叶。在四种情绪类型中，氧环境对HVLA情绪状态下脑活动的影响最小，其余均表现出显著差异。
