School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai, P.R. China.
Comput Methods Biomech Biomed Engin. 2021 Aug;24(10):1073-1084. doi: 10.1080/10255842.2020.1867115. Epub 2021 Mar 14.
Implants, tissue engineering scaffolds made of biodegradable polymers are widely used in biomedical engineering. The degradation of polymers plays a critical role in the effectiveness of these applications. In this paper, the mechanism of the hydrolytic degradation affected by the flow medium is studied. The results indicate that both high porosity and dynamic conditions may significantly slow down degradation speed. A critical value of the Reynolds number is found to exist. When the Reynolds number is higher than the critical value, the autocatalysis was suppressed. The models reported in this article might serve as a guide to design 3D biodegradable implants.
可生物降解聚合物制成的植入物和组织工程支架在生物医学工程中得到了广泛的应用。聚合物的降解在这些应用的效果中起着关键作用。本文研究了受流动介质影响的水解降解机制。结果表明，高孔隙率和动态条件都可能显著降低降解速度。发现存在一个临界雷诺数。当雷诺数高于临界值时，自催化作用受到抑制。本文报道的模型可以为设计 3D 可生物降解植入物提供指导。
