从（Batalin）Iljinskaja 的叶子中分离得到的两种新三萜类化合物。

Two new triterpenoids from the leaves of (Batalin) Iljinskaja.

机构信息

Department of TCMs Pharmaceuticals, School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing, P.R. China.

Laboratory of Translational Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, P.R. China.

出版信息

Nat Prod Res. 2022 Aug;36(15):3938-3944. doi: 10.1080/14786419.2021.1900845. Epub 2021 Mar 15.

DOI:10.1080/14786419.2021.1900845

PMID:33719794

Abstract

Two previously undescribed triterpenoids (), along with thirteen known compounds () were isolated from a CHCl-soluble extract of the leaves of . Their structures were established on the basis of chemical and spectroscopic approaches. These compounds were assessed for their therapeutic effects on diabetic nephropathy (DN)-evoked fibrosis through High-Glucose and transforming growth factor-β1 (TGF-β1) challenged HK-2 cells. Among them, compounds , and could remarkedly decrease the level of fibronectin to relieve DN with 27.66 ± 2.77%, 6.09 ± 0.57% and 17.74 ± 5.83% inhibition rate at 10 μM, 10 μM and 1 μM, respectively.

摘要

从的叶子的 CHCl 可溶提取物中分离得到两种以前未描述的三萜类化合物（），以及 13 种已知化合物（）。基于化学和光谱方法确定了它们的结构。通过高葡萄糖和转化生长因子-β1（TGF-β1）挑战的 HK-2 细胞，评估这些化合物对糖尿病肾病（DN）引起的纤维化的治疗效果。其中，化合物、和可以显著降低纤连蛋白水平，抑制率分别为 27.66±2.77%、6.09±0.57%和 17.74±5.83%，从而缓解 DN，在 10 μM、10 μM 和 1 μM 时。