Department of Nutrition and Dietetics, Faculty of Health Sciences, Near East University, Nicosia, Cyprus.
Department of Biochemistry, Faculty of Pharmacy, Near East University, Nicosia, Cyprus.
Arch Physiol Biochem. 2023 Apr;129(2):555-561. doi: 10.1080/13813455.2021.1893338. Epub 2021 Mar 15.
Diabetes mellitus is a significant health problem that is caused by chronic hyperglycaemia as a result of inadequate insulin production or ineffective insulin action in the body. In recent years, many new pharmacological and non-pharmacological therapies have been developed for improving pancreatic insulin secretion and insulin resistance. Resveratrol is a natural and biologically active stilbenoid polyphenol present in various plant species and has the potential to benefit diabetes. The anti-diabetic actions of resveratrol have also been extensively studied in diabetic human and animal models. Moreover, resveratrol might affect insulin sensitivity by regulating visceral fat derivated adipokine levels. The use of resveratrol in combination with anti-diabetic therapies or alone may have significant potential for the management of diabetes mellitus. This review provides an overview of the anti-diabetic action of resveratrol as well as the possible mechanisms that have an effect on insulin secretion and insulin resistance in diabetics.
糖尿病是一种严重的健康问题，其由慢性高血糖引起，这是由于体内胰岛素分泌不足或胰岛素作用失效所致。近年来，已经开发出许多新的药理学和非药理学疗法来改善胰腺胰岛素分泌和胰岛素抵抗。白藜芦醇是一种天然的、具有生物活性的芪类多酚，存在于各种植物物种中，具有改善糖尿病的潜力。白藜芦醇的抗糖尿病作用在糖尿病人类和动物模型中也得到了广泛研究。此外，白藜芦醇可能通过调节内脏脂肪衍生的脂肪因子水平来影响胰岛素敏感性。白藜芦醇与抗糖尿病疗法联合使用或单独使用可能对糖尿病的管理具有重要的潜在作用。本综述提供了白藜芦醇的抗糖尿病作用概述，以及可能影响糖尿病患者胰岛素分泌和胰岛素抵抗的机制。
