Department of Pharmacology, Faculty of Pharmacy, University of Erciyes, 38039 Kayseri, Turkey.
Department of Pharmacology, Faculty of Pharmacy, University of Erciyes, 38039 Kayseri, Turkey.
Biomed Pharmacother. 2017 Nov;95:230-234. doi: 10.1016/j.biopha.2017.08.070. Epub 2017 Sep 12.
Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia. The disease results from the defects of insulin secretion and/or action. Resveratrol is a non-flavonoid polyphenol that naturally occurs as phytoalexin. The shell and stem of Vitis vinifera L. (Vitaceae) are the richest source of this compound. In addition to various in vitro and in vivo studies revealing the effectiveness of resveratrol in DM, there are many clinical trials indicating that resveratrol has the potential to benefit in DM patients. The therapeutic action of this compound in relation to diabetes is complex and involves in several beneficial roles. In view of this, clinical studies are necessary to elucidate these roles. In the near future, the use of resveratrol, alone or in combination with current anti-diabetic therapies, might be a conventional approach to effectively manage DM or its complications. This mini-review provides a critical overview of currently available clinical studies examining the effects of resveratrol in DM last decade.
糖尿病(DM)是一种以高血糖为特征的代谢性疾病。该疾病是由于胰岛素分泌和/或作用缺陷引起的。白藜芦醇是一种非黄酮类多酚,天然存在于植物抗毒素中。葡萄(葡萄科)的壳和茎是这种化合物最丰富的来源。除了各种体外和体内研究表明白藜芦醇在 DM 中的有效性外,还有许多临床试验表明白藜芦醇有可能使 DM 患者受益。这种化合物在糖尿病中的治疗作用很复杂,涉及几个有益的作用。鉴于此,有必要进行临床研究来阐明这些作用。在不久的将来,单独使用或与现有的抗糖尿病疗法联合使用白藜芦醇可能成为有效治疗 DM 或其并发症的常规方法。本综述简要概述了过去十年中检查白藜芦醇在 DM 中作用的现有临床研究。