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COVID-19 可能会增加 G6PD 缺乏症患者的血栓形成和溶血风险。

COVID-19 may enhance risk of thrombosis and hemolysis in the G6PD deficient patients.

机构信息

Koc University School of Medicine, Istanbul, Turkey.

Koc University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2021;40(5):505-517. doi: 10.1080/15257770.2021.1897457. Epub 2021 Mar 15.

Abstract

COVID-19 has become a major public health problem since December, 2019 and no highly effective drug has been found until now. Numbers of infected people and deaths by COVID-19 are increasing every day worldwide, therefore self-isolation and protection are highly recommended to prevent the spread of the virus and especially to protect major risk groups such as the elderly population and people with comorbidities including diabetes, hypertension, cancer, cardiovascular diseases and metabolic syndrome. On the other hand, young people without any secondary disease have died by COVID-19 as well. In this study we compared two male patients infected by COVID-19 at the same age and one of them was diagnosed with G6PD deficiency. Both COVID-19 and G6PD deficiency enhance the risk of hemolysis and thrombosis. Serum biochemistry, hemogram and immunological parameters showed that risk of hemolysis and thrombosis may increase in the G6PD deficient patient infected by COVID-19.

摘要

自 2019 年 12 月以来,COVID-19 已成为一个主要的公共卫生问题,到目前为止还没有发现非常有效的药物。全球每天感染 COVID-19 的人数和死亡人数都在增加,因此强烈建议自我隔离和保护,以防止病毒传播,特别是要保护老年人和患有糖尿病、高血压、癌症、心血管疾病和代谢综合征等合并症的高危人群。另一方面,也有年轻人没有任何其他疾病死于 COVID-19。在这项研究中,我们比较了两名年龄相同的 COVID-19 感染男性患者,其中一人被诊断为 G6PD 缺乏症。COVID-19 和 G6PD 缺乏症都会增加溶血和血栓形成的风险。血清生化、血常规和免疫参数表明,COVID-19 感染的 G6PD 缺乏症患者的溶血和血栓形成风险可能增加。

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