葡萄糖-6-磷酸脱氢酶（G6PD）缺乏、氧化还原平衡与病毒感染：对严重急性呼吸综合征冠状病毒 2（SARS-CoV-2，即 COVID-19）的影响。
G6PD deficiency, redox homeostasis, and viral infections: implications for SARS-CoV-2 (COVID-19).
机构信息
Department of Medical Laboratory Science and Biotechnology, Yuanpei University of Medical Technology, Hsinchu, Taiwan.
Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
出版信息
Free Radic Res. 2021 Apr;55(4):364-374. doi: 10.1080/10715762.2020.1866757. Epub 2021 Jan 6.
Abstract
The COVID-19 pandemic has so far affected more than 45 million people and has caused over 1 million deaths worldwide. Infection with SARS-CoV-2, the pathogenic agent, which is associated with an imbalanced redox status, causes hyperinflammation and a cytokine storm, leading to cell death. Glucose-6-phosphate dehydrogenase (G6PD) deficient individuals may experience a hemolytic crisis after being exposed to oxidants or infection. Individuals with G6PD deficiency are more susceptible to coronavirus infection than individuals with normally functioning G6PD. An altered immune response to viral infections is found in individuals with G6PD deficiency. Evidence indicates that G6PD deficiency is a predisposing factor of COVID-19.
摘要
到目前为止，COVID-19 大流行已影响了超过 4500 万人，并在全球范围内导致了超过 100 万人死亡。感染 SARS-CoV-2 病原体与氧化还原状态失衡有关，会导致过度炎症和细胞因子风暴，导致细胞死亡。葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症患者在接触氧化剂或感染后可能会发生溶血危机。与 G6PD 正常功能的个体相比，G6PD 缺乏症患者更容易感染冠状病毒。G6PD 缺乏症患者的病毒感染免疫反应发生改变。有证据表明，G6PD 缺乏症是 COVID-19 的一个易感因素。
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