Neuropharmacology Research Laboratory, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi-110 017, India.
Curr Drug Res Rev. 2021;13(3):166-171. doi: 10.2174/2589977513666210315095133.
Evidence has emerged over the last 2 decades to ascertain the proof of concepts viz. mitochondrial dysfunction, inflammation-derived oxidative damage and cytokine-induced toxicity that play a significant role in Parkinson's disease (PD). The available pharmacotherapies for PD are mainly symptomatic and typically indicate L-DOPA to restrain dopamine deficiency and its consequences. In the 21st century, the role of antibiotics has emerged at the forefront of medicines in health and human illness. There are several experimental and pre-clinical evidences that support the potential use of antibiotics as a neuroprotective agent. The astonishing effects of antibiotics and their neuroprotective properties against neurodegeneration and neuro-inflammation would be phenomenal for the development of effective therapy against PD. Antibiotics are also testified as useful in not only preventing the formation of alpha-synuclein but also acting on mitochondrial dysfunction and neuro-inflammation. Thus, the possible therapy with antibiotics in PD would impact both pathways leading to neuronal cell death in substantia nigra and pars compacta in the midbrain. Moreover, the antibiotic-based pharmacotherapy will open a scientific research avenue to add more to the evidence-based and rational use of antibiotics for the treatment and management of PD and other neurodegenerative disorders.
在过去的 20 年中，出现了大量证据来证实各种概念，即线粒体功能障碍、炎症衍生的氧化损伤和细胞因子诱导的毒性，这些在帕金森病（PD）中起着重要作用。PD 的现有药物疗法主要是对症治疗，通常采用 L-DOPA 来抑制多巴胺缺乏及其后果。在 21 世纪，抗生素在药物治疗健康和人类疾病方面的作用已成为前沿。有几项实验和临床前证据支持将抗生素用作神经保护剂。抗生素令人惊讶的作用及其对神经退行性变和神经炎症的神经保护特性将为开发针对 PD 的有效疗法带来巨大的突破。抗生素也被证明不仅可以预防α-突触核蛋白的形成，还可以作用于线粒体功能障碍和神经炎症。因此，抗生素在 PD 中的可能治疗方法将影响中脑黑质和 pars compacta 中导致神经元细胞死亡的两条途径。此外，基于抗生素的药物治疗将开辟一条科学研究途径，为基于循证和合理使用抗生素治疗和管理 PD 及其他神经退行性疾病提供更多证据。
