人类免疫球蛋白D基因片段：一个新D基因片段的分离及D1基因片段的多态性缺失
Human immunoglobulin D segments: isolation of a new D segment and polymorphic deletion of the D1 segment.
作者信息
Zong S Q, Nakai S, Matsuda F, Lee K H, Honjo T
机构信息
Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan.
出版信息
Immunol Lett. 1988 Apr;17(4):329-33. doi: 10.1016/0165-2478(88)90006-5.
We have isolated and identified a new human germline D segment which is not physically linked to the known D cluster. The nucleotide sequence of the new D segment was highly homologous with the known D segments. Frequent polymorphic deletion of the D1 segment was found in the Japanese population. Nucleotide sequences surrounding the deletion indicate that homologous recombination is likely to be responsible for the deletion of the D1 segment.
我们分离并鉴定出了一个新的人类种系D片段，它在物理上与已知的D簇不相连。新D片段的核苷酸序列与已知的D片段高度同源。在日本人群中发现了D1片段的频繁多态性缺失。缺失周围的核苷酸序列表明，同源重组可能是D1片段缺失的原因。
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