Department of Physical Therapy, University of Toronto, 500 University Avenue, Toronto, ON, M5G 1V7, Canada.
Department of Family and Community Medicine, University of Toronto, 500 University Avenue, Toronto, ON, M5G 1V7, Canada.
J Immigr Minor Health. 2021 Dec;23(6):1305-1342. doi: 10.1007/s10903-021-01161-3. Epub 2021 Mar 8.
This paper provides a narrative review of the existing literature on differences in demographic and biological features of breast cancer at time of diagnosis between Black and White women in Canada, the United Kingdom and the United States. Electronic database searches for published peer-reviewed articles on this topic were conducted, and 78 articles were included in the final narrative review. Differences between Black and White women were compared for eight categories including age, tumour stage, size, grade, lymph node involvement, and hormone status. Black women were significantly more likely to present with less favourable tumour features at the time of diagnosis than White women. Significant differences were reported in age at diagnosis, tumour stage, size, grade and hormone status, particularly triple negative breast cancer. Limitations on the generalizability of the review findings are discussed, as well as the implications of these findings on future research, especially within the Canadian context.
本文对加拿大、英国和美国的黑人和白人女性在乳腺癌诊断时的人口统计学和生物学特征差异的现有文献进行了叙述性综述。对该主题的已发表同行评议文章进行了电子数据库检索，最终叙述性综述纳入了 78 篇文章。比较了黑人女性和白人女性在 8 个类别中的差异，包括年龄、肿瘤分期、大小、分级、淋巴结受累和激素状态。黑人女性在诊断时的肿瘤特征明显不如白人女性有利。在诊断年龄、肿瘤分期、大小、分级和激素状态方面，特别是三阴性乳腺癌，报告了显著差异。讨论了综述结果的普遍性限制，以及这些发现对未来研究的意义，特别是在加拿大的背景下。
