Hacioglu Aysa, Gundogdu Aycan, Nalbantoglu Ufuk, Karaca Zuleyha, Urhan Muhammed Emre, Sahin Serdar, Dokmetas Hatice Sebile, Kadioglu Pinar, Kelestimur Fahrettin
Department of Endocrinology, School of Medicine, Erciyes University, Kayseri, Turkey.
Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Pituitary. 2021 Aug;24(4):600-610. doi: 10.1007/s11102-021-01137-4. Epub 2021 Mar 15.
Microbiota has crucial biological importance for human well-being. Bidirectional interaction exists between microbiota and the host, and there have been no studies investigating this interaction in patients with acromegaly. We aimed to analyze the composition of microbiota in patients with newly diagnosed acromegaly.
Stool samples were obtained from the patients with newly diagnosed acromegaly in the Endocrinology Clinic of Erciyes University Medical School. The composition of microbiota was analyzed, and the results were compared to healthy volunteers matched to the patients in terms of age, gender and body mass index.
Seven patients (three male, four female) with a mean age of 48 ± 17.6 years were included in the study. The stool analysis revealed a significantly lower bacterial diversity in the patients with acromegaly. Bacteroidetes phylum was predominating in the patient group, and Firmicutes/Bacteroidetes ratio was altered significantly. Bifidobacterium, Collinsella, Bacteroides, Butyricimonas, Clostridium, Oscillospira, and Dialister were predominating in the control group.
The gut microbiota is significantly altered in patients with newly diagnosed acromegaly. Further prospective studies are needed to elucidate the causative relationship between acromegaly, colorectal pathologies, and microbial alterations.
微生物群对人类健康具有至关重要的生物学意义。微生物群与宿主之间存在双向相互作用，而目前尚无关于肢端肥大症患者这种相互作用的研究。我们旨在分析新诊断肢端肥大症患者的微生物群组成。
从埃尔西耶斯大学医学院内分泌科门诊新诊断的肢端肥大症患者中获取粪便样本。分析微生物群的组成，并将结果与在年龄、性别和体重指数方面与患者匹配的健康志愿者进行比较。
该研究纳入了7例平均年龄为48±17.6岁的患者（3例男性，4例女性）。粪便分析显示肢端肥大症患者的细菌多样性显著降低。患者组中拟杆菌门占主导，厚壁菌门/拟杆菌门的比例发生了显著变化。对照组中双歧杆菌、柯林斯菌、拟杆菌、丁酸单胞菌、梭菌、颤螺菌和戴阿利斯特菌占主导。
新诊断的肢端肥大症患者的肠道微生物群有显著改变。需要进一步的前瞻性研究来阐明肢端肥大症、结直肠疾病和微生物改变之间的因果关系。
