靶向肠道微生物群与 2 型糖尿病患者体成分的相关性研究。
The Association of Targeted Gut Microbiota with Body Composition in Type 2 Diabetes Mellitus.
机构信息
Department of Microbiology and Immunology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
出版信息
Int J Med Sci. 2021 Jan 1;18(2):511-519. doi: 10.7150/ijms.51164. eCollection 2021.
The association between body composition and gut microbiota in type 2 diabetes mellitus (DM) remains unknown. To elucidate the correlation of body composition and gut microbiota, we conducted a clinical study to enroll 179 patients with type 2 DM. Body composition of lean tissue index (LTI) and fat tissue index was measured by Body Composition Monitor. Eight pairs of 16S rRNA gene primers specific to Firmicutes, Bacteroidetes, the group, , , , , and were used to measure their abundance by quantitative polymerase chain reaction. The results showed that type 2 DM with higher abundance of phylum Firmicutes and a higher ratio of phyla Firmicutes to Bacteroidetes (phyla F/B ratio) had higher LTI. This significant correlation between phyla F/B ratio and LTI was especially evident in type 2 DM with high body mass index, and independent of glycemic control or dipeptidyl peptidase-4 inhibitor usage. In conclusion, our study demonstrated the positive association of LTI with the abundance of phylum Firmicutes and the phyla F/B ratio in type 2 DM.
2 型糖尿病（DM）患者的体成分与肠道微生物群之间的关系尚不清楚。为了阐明体成分和肠道微生物群之间的相关性，我们进行了一项临床研究，共纳入 179 例 2 型 DM 患者。通过身体成分监测仪测量瘦组织指数（LTI）和脂肪组织指数。使用 8 对针对厚壁菌门、拟杆菌门、变形菌门、放线菌门、梭杆菌门、疣微菌门和螺旋体门的 16S rRNA 基因引物，通过定量聚合酶链反应测量它们的丰度。结果表明，厚壁菌门丰度较高和厚壁菌门与拟杆菌门比值（phyla F/B ratio）较高的 2 型 DM 患者 LTI 较高。这种 phyla F/B 比值与 LTI 之间的显著相关性在高体重指数的 2 型 DM 患者中尤为明显，且独立于血糖控制或二肽基肽酶-4 抑制剂的使用。总之，我们的研究表明，LTI 与 2 型 DM 中厚壁菌门的丰度和 phyla F/B 比值呈正相关。
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