Yue W L
Department of Otolaryngology, Pingdingshan People's Hospital No. 1, Henan Province (People's Republic of China).
Int J Pediatr Otorhinolaryngol. 1988 Feb;15(1):87-92. doi: 10.1016/0165-5876(88)90054-7.
Otolaryngological manifestations of 90 patients (of which 50 were under 16 years) with immune thrombocytopenia purpura (I.T.P.) appearing at the Pingdingshan Hematological Institute over 10 years have been studied. Among the sick children, epistaxis was the most common complaint (of which 60% responded to nasal packing), followed by gum, buccal, conjunctive, tongue, lips, eyelids, facial and throat bleeding, in this order. Severity and recurrence were correlated with the sick children's condition: the presence or absence of local trauma and infection, blood platelet level and capillary fragility, especially in acute I.T.P. Some therapeutic principles for these associated abnormalities are recommended. Other conditions included: hearing loss, vertigo, or dizziness, tinnitus, facial paralysis and so on. Our conclusion is that the role of immune responses may be important in the etiopathogenesis of these non-hemorrhagic abnormalities, and should not be ignored in treating the problems as result of I.T.P. In this paper, these immunological and pathological mechanisms implicated in the two problems described above are also discussed.
对平顶山市血液病研究所10年来收治的90例免疫性血小板减少性紫癜（ITP）患者（其中50例年龄在16岁以下）的耳鼻喉科表现进行了研究。在患病儿童中，鼻出血是最常见的症状（其中60%对鼻腔填塞有反应），其次依次为牙龈、颊部、结膜、舌、唇、眼睑、面部和咽喉出血。严重程度和复发与患病儿童的病情相关：局部创伤和感染的存在与否、血小板水平和毛细血管脆性，尤其是在急性ITP中。针对这些相关异常情况推荐了一些治疗原则。其他情况包括：听力丧失、眩晕或头晕、耳鸣、面瘫等。我们的结论是，免疫反应在这些非出血性异常的发病机制中可能起重要作用，在治疗ITP所致问题时不应被忽视。本文还讨论了上述两个问题所涉及的免疫和病理机制。
