Umemura K, Asai Y, Uematsu T, Nakashima M
Department of Pharmacology, Hamamatsu University School of Medicine, Japan.
Eur Arch Otorhinolaryngol. 1993;250(6):342-4. doi: 10.1007/BF00188383.
Since thromboxane (TX) A2 causes vasoconstriction and platelet aggregation, we evaluation the effect of a TXA2 receptor antagonist (vapiprost) and a TXA2 synthetase inhibitor (Y-20811) on a microcirculation disorder in the rat inner ear that was induced by a photochemical reaction between an intravenous injection of rose bengal (RB) and green light. A gradual decrease of the cochlear action potential (CAP) to an 8 kHz sound stimulus was measured with an electrocochleogram and occurred after the RB injection. The CAP then disappeared 5 min after the injection of RB. Both vapiprost and Y-20811 significantly prolonged the time required to complete suppression of the CAP as compared with saline as control. These findings indicate that TXA2 may play an important role in microcirculation disorders in the rat inner ear.
由于血栓素（TX）A2会引起血管收缩和血小板聚集，我们评估了TX A2受体拮抗剂（前列环醇）和TX A2合成酶抑制剂（Y - 20811）对大鼠内耳微循环障碍的影响，该微循环障碍是由静脉注射孟加拉玫瑰红（RB）与绿光之间的光化学反应诱导产生的。用电耳蜗图测量了对8 kHz声音刺激的耳蜗动作电位（CAP）的逐渐下降情况，其在RB注射后出现。然后，CAP在RB注射后5分钟消失。与作为对照的生理盐水相比，前列环醇和Y - 20811均显著延长了完全抑制CAP所需的时间。这些发现表明，TX A2可能在大鼠内耳微循环障碍中起重要作用。
