Department of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, United States.
Department of Neuroscience, Brain Science Institute, and Kavli Neuroscience Discovery Institute, Johns Hopkins School of Medicine, Baltimore, United States.
Elife. 2021 Mar 15;10:e64327. doi: 10.7554/eLife.64327.
We examined the relationships between activity in the locus coeruleus (LC), activity in the primary somatosensory cortex (S1), and pupil diameter in mice performing a tactile detection task. While LC spiking consistently preceded S1 membrane potential depolarization and pupil dilation, the correlation between S1 and pupil was more heterogeneous. Furthermore, the relationships between LC, S1, and pupil varied on timescales of sub-seconds to seconds within trials. Our data suggest that pupil diameter can be dissociated from LC spiking and cannot be used as a stationary index of LC activity.
我们研究了在执行触觉检测任务的小鼠中蓝斑（LC）的活动、初级体感皮层（S1）的活动和瞳孔直径之间的关系。虽然 LC 的尖峰活动始终先于 S1 膜电位去极化和瞳孔扩张，但 S1 和瞳孔之间的相关性更为复杂。此外，在试验内的亚秒到秒时间尺度内，LC、S1 和瞳孔之间的关系也有所不同。我们的数据表明，瞳孔直径可以与 LC 尖峰活动分离，不能作为 LC 活动的静态指标。
