Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA.
Psychiatry Res. 2021 May;299:113843. doi: 10.1016/j.psychres.2021.113843. Epub 2021 Mar 3.
The genetic basis of mood disorders can, theoretically, provide diagnostic information in scenarios of clinical uncertainty. Therefore, we examined the available body of knowledge on the association between polygenic risk scores for bipolar disorder (BP-PRSs) and pediatric bipolar spectrum and related disorders. We performed a literature search through PubMed in March of 2020. The following variables were extracted from relevant studies: population age, study sample size, source of polygenic risk scores, source of data, the primary goal of the study, the assessments used during the course of the study, and the main findings/outcomes of each study. BP-PRSs were associated with deficits in executive functioning and the diagnosis of attention deficit/hyperactivity disorder (ADHD). Three studies included in our analysis directly compared major depressive disorder (MDD)-PRSs to BP-PRSs in youth. Results showed that MDD-PRSs, and not BP-PRSs, were associated with ADHD symptoms, internalizing problems, and social problems. ADHD-PRSs were associated with conduct problems, depressive symptomatology, and externalizing disorders symptoms. Findings revealed that ADHD-PRSs were more clearly associated with emotional reactivity, emotional dysregulation, and irritability-frequent correlates of pediatric BP disorder. These findings suggest that ADHD-PRSs may have an important contribution to the development of mood related problems in youth.
心境障碍的遗传基础从理论上可以为临床不确定情况下的诊断提供信息。因此，我们研究了双相障碍（BP-PRSs）和儿童双相谱系及相关障碍的多基因风险评分与儿科之间的现有知识关联。我们于 2020 年 3 月通过 PubMed 进行了文献检索。从相关研究中提取了以下变量：人群年龄、研究样本量、多基因风险评分来源、数据来源、研究的主要目标、研究过程中使用的评估方法以及每项研究的主要发现/结果。BP-PRSs 与执行功能障碍和注意力缺陷多动障碍（ADHD）的诊断有关。我们分析中包含的三项研究直接比较了青年人群中的重度抑郁症（MDD）-PRSs 和 BP-PRSs。结果表明，MDD-PRSs 而非 BP-PRSs 与 ADHD 症状、内化问题和社会问题有关。ADHD-PRSs 与行为问题、抑郁症状和外化障碍症状有关。研究结果表明，ADHD-PRSs 与情绪反应性、情绪调节障碍和易激惹更为相关，这些都是儿童 BP 障碍的常见相关症状。这些发现表明，ADHD-PRSs 可能对青少年情绪相关问题的发展有重要贡献。
