Institute for Physical Chemistry, CeNIDE, University of Duisburg-Essen, Essen, Germany.
J Microencapsul. 2021 Aug;38(5):276-284. doi: 10.1080/02652048.2021.1903594. Epub 2021 Apr 6.
The design of an encapsulation system consisting of a synthetic peptide which is fully biodegradable into non-toxic constituents. This system should be capable of encapsulating perfluorinated hydrocarbons and should be a promising basis for oxygen carriers to be used as artificial blood replacement. A diblock-peptide is synthesised following a phosgene-free method and characterised by H-NMR. Subsequently, this diblock-peptide is self-assembled with perfluorodecalin (PFD) to form PFD-filled capsules as potential artificial oxygen carriers allowing for rapid oxygen uptake and release. The diblock-peptide Bu-PAsp-PPhe is successfully synthesised and used to encapsulate PFD. The capsules have a spherical shape with an average diameter of 360 nm in stable aqueous dispersion. NMR measurements prove their physical capability for reversible uptake and release of oxygen. The resulting capsules are expected to be fully biodegradable and possibly could act as oxygen carriers for artificial blood replacement.
设计一种由完全可生物降解为无毒成分的合成肽组成的封装系统。该系统应能够封装全氟碳化合物，并且可能成为用作人工血液替代品的氧载体的有前途的基础。采用无光气法合成二嵌段肽，并通过 H-NMR 进行表征。随后，该二嵌段肽与全氟癸烷（PFD）自组装形成 PFD 填充胶囊，作为潜在的人工氧载体，可实现快速氧气摄取和释放。成功合成了 Bu-PAsp-PPhe 二嵌段肽并用于封装 PFD。胶囊在稳定的水性分散体中具有球形形状，平均直径为 360nm。NMR 测量证明了它们可逆地摄取和释放氧气的物理能力。预计所得胶囊完全可生物降解，并且可能可用作人工血液替代品的氧载体。
