Javadi Maryam, Deravi Somayeh, Zarei Shabnam, Mahdavi Nader, Ranjbaran Mehdi
Children Growth Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.
Department of Nutrition, School of Health, Qazvin University of Medical Sciences, Qazvin, Iran.
J Matern Fetal Neonatal Med. 2022 Dec;35(25):5813-5820. doi: 10.1080/14767058.2021.1895738. Epub 2021 Mar 15.
This systematic review and meta-analysis study aimed to estimate the overall prevalence of Glucose-6-phosphate dehydrogenase (G6PD) deficiency in neonates with jaundice who were admitted to hospitals in Iran.
In this systematic review and meta-analysis, we searched PubMed/Medline, Scopus, ISI Web of Sciences, and Iranian Local databases up to December 2019.We calculated Prevalence and 95% Confidence Interval (95% CI) of G6PD deficiency as summary measures. We conducted subgroup analysis based on the sex and quality of studies, while meta-regression were applied for investigating the effect of years of studies and years of publication on the pooled prevalence. We applied sensitivity analysis to investigate the effect of excluding each study on the pooled prevalence estimation.
The total sample size was 9799 people. The pooled prevalence of G6PD deficiency among neonates with jaundice in Iran was 7.0% (95% CI: 5.5-8.5%). The results of subgroup analysis showed that, pooled prevalence of G6PD deficiency among male neonate (12.1%, 95%CI: 7.6-16.7%) was more prevalent that female (3.00%, 95%CI: 1.1-4.9%). Based on the sensitivity analysis, lower and higher pooled prevalence of G6PD deficiency was observed 5.8% (95%CI: 4.7-6.9%) and 7.3% (95%CI: 5.7-8.8%) respectively by excluding each study.
The overall prevalence of G6PD deficiency was 7% in Iranian neonates with Jaundice. Prevalence was high in male and early hours of life. We recommend screening test for G6PD deficiency in neonates to prevent its complications.
本系统评价和荟萃分析旨在估计伊朗医院收治的黄疸新生儿中葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症的总体患病率。
在本系统评价和荟萃分析中，我们检索了截至2019年12月的PubMed/Medline、Scopus、ISI科学网和伊朗本地数据库。我们计算了G6PD缺乏症的患病率和95%置信区间（95%CI）作为汇总指标。我们根据研究的性别和质量进行亚组分析，同时应用meta回归来研究研究年份和发表年份对合并患病率的影响。我们应用敏感性分析来研究排除每项研究对合并患病率估计的影响。
总样本量为9799人。伊朗黄疸新生儿中G6PD缺乏症的合并患病率为7.0%（95%CI：5.5-8.5%）。亚组分析结果显示，男性新生儿中G6PD缺乏症的合并患病率（12.1%，95%CI：7.6-16.7%）高于女性（3.00%，95%CI：1.1-4.9%）。基于敏感性分析，通过排除每项研究，G6PD缺乏症的合并患病率分别为5.8%（95%CI：4.7-6.9%）和7.3%（95%CI：5.7-8.8%）。
伊朗黄疸新生儿中G6PD缺乏症的总体患病率为7%。男性和生命早期患病率较高。我们建议对新生儿进行G6PD缺乏症筛查以预防其并发症。
