Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, 300 Longwood Avenue, Bader 3, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, 300 Longwood Avenue, Bader 3, Boston, MA 02115, USA; Rush Medical College at Rush University, 600 S. Paulina Street, Chicago, IL 60612, USA.
J Pediatr Surg. 2021 Sep;56(9):1564-1569. doi: 10.1016/j.jpedsurg.2021.01.030. Epub 2021 Feb 13.
We extended our pilot study in infants following long-gap esophageal atresia (LGEA) repair to report head circumference, an easily obtainable indirect measure of brain size. Data are presented in the context of previously reported body weight and T2-weighted MRI measures of intracranial and brain volumes.
Clinical information and head circumference were obtained for term-born (n = 13) and premature (n = 13) infants following LGEA repair with Foker process, as well as healthy term-born controls (n = 20) <1-year corrected age who underwent non-sedated research MRI. General Linear Model univariate analysis with corrected age at scan as a covariate and Bonferroni adjusted p values assessed group differences.
We report no difference in head circumference between the three groups. Such findings paralleled trends in body weight and total intracranial volume but not in brain volume as previously reported for the same pilot cohort.
Results suggest uncompromised somatic and head growth after repair of LGEA. In contrast, a novel finding of discrepancy between head circumference (novel data) and brain size (previously published data) in the same cohort suggests that head circumference might not be the best indirect measure of brain size in selected group of patients.
我们将在长段食管闭锁（LGEA）修复后的婴儿中进行的初步研究扩展，以报告头围，这是一种易于获得的大脑大小的间接测量方法。本研究的数据是在之前报告的体重和 T2 加权 MRI 测量的颅内和脑容量的基础上呈现的。
我们收集了 Foker 手术修复 LGEA 的足月（n=13）和早产（n=13）婴儿以及<1 岁校正年龄的健康足月婴儿（n=20）的临床信息和头围。使用单变量分析的一般线性模型，以扫描时的校正年龄为协变量，并进行 Bonferroni 校正的 p 值检验，以评估组间差异。
我们报告三组间头围无差异。这些结果与体重和总颅内体积的趋势一致，但与同一初步队列中之前报道的脑容量趋势不一致。
结果表明 LGEA 修复后，躯体和头部生长不受影响。相比之下，在同一队列中，头围（新数据）和脑容量（之前发表的数据）之间存在差异，这表明头围可能不是特定患者群体中大脑大小的最佳间接测量方法。
