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Timing and dosage may be the key in the realisation of hydroxychloroquine + azithromycin treatment benefit in Covid-19 elderly patients.时机和剂量可能是在新冠病毒肺炎老年患者中实现羟氯喹啉联合阿奇霉素治疗益处的关键。
Int J Antimicrob Agents. 2021 Apr;57(4):106314. doi: 10.1016/j.ijantimicag.2021.106314. Epub 2021 Mar 17.
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Hydroxychloroquine + azithromycin treatment in elderly patients.老年患者的羟氯喹啉 + 阿奇霉素治疗
Int J Antimicrob Agents. 2021 Apr;57(4):106313. doi: 10.1016/j.ijantimicag.2021.106313. Epub 2021 Mar 11.
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J Microbiol Immunol Infect. 2021 Feb;54(1):109-112. doi: 10.1016/j.jmii.2020.09.003. Epub 2020 Oct 5.
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Lessons learnt from hydroxychloroquine/azithromycin in treatment of COVID-19.羟氯喹/阿奇霉素治疗 COVID-19 的经验教训。
Eur Respir J. 2022 Jan 6;59(1). doi: 10.1183/13993003.02002-2021. Print 2022 Jan.
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Hydroxychloroquine with or without Azithromycin in Covid-19. Reply.新冠疫情中使用或不使用阿奇霉素的羟氯喹。回复。
N Engl J Med. 2021 Jan 14;384(2):191. doi: 10.1056/NEJMc2031780. Epub 2020 Dec 2.
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Investigation of QT Prolongation with Hydroxychloroquine and Azithromycin for the Treatment of COVID-19.羟氯喹和阿奇霉素治疗新型冠状病毒肺炎（COVID-19）时QT间期延长的研究
J Coll Physicians Surg Pak. 2020 Oct;30(10):153-157. doi: 10.29271/jcpsp.2020.supp2.S153.
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Am J Epidemiol. 2021 Nov 2;190(11):2405-2419. doi: 10.1093/aje/kwab183.
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The impact of hydroxychloroquine and azithromycin on the corrected qt interval in patients with the novel Coronavirus disease 2019.羟氯喹和阿奇霉素对新型冠状病毒病患者校正 QT 间期的影响。
Rev Assoc Med Bras (1992). 2021 Jul;67(7):979-984. doi: 10.1590/1806-9282.20210380.
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Reply to Alizazgar J. Dangers of the use of hydroxychloroquine and azithromycin combination in COVID-19 patients.回复阿利扎加（Alizazgar）J. 关于在新冠病毒肺炎患者中联合使用羟氯喹和阿奇霉素的风险
Travel Med Infect Dis. 2021 Mar-Apr;40:101984. doi: 10.1016/j.tmaid.2021.101984. Epub 2021 Feb 5.
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Usefulness and safety of self-electrocardiographic monitoring during treatment with hydroxychloroquine and azithromycin in COVID-19 patients.新型冠状病毒肺炎患者使用羟氯喹和阿奇霉素治疗期间自我心电图监测的有效性和安全性
Rev Esp Cardiol (Engl Ed). 2021 Jan;74(1):108-111. doi: 10.1016/j.rec.2020.08.020. Epub 2020 Oct 1.

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Hypertension related toxicity of chloroquine explains its failure against COVID-19: Based on rat model.氯喹与高血压相关的毒性解释了其抗COVID-19失败的原因：基于大鼠模型。
Front Pharmacol. 2022 Nov 30;13:1051694. doi: 10.3389/fphar.2022.1051694. eCollection 2022.
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Safety considerations of chloroquine in the treatment of patients with diabetes and COVID-19.氯喹治疗糖尿病合并 COVID-19 患者的安全性考虑。
Chem Biol Interact. 2022 Jul 1;361:109954. doi: 10.1016/j.cbi.2022.109954. Epub 2022 Apr 22.
3
Hydroxychloroquine + azithromycin treatment in elderly patients.老年患者的羟氯喹啉 + 阿奇霉素治疗
Int J Antimicrob Agents. 2021 Apr;57(4):106313. doi: 10.1016/j.ijantimicag.2021.106313. Epub 2021 Mar 11.

本文引用的文献

1
Hydroxychloroquine in Hospitalized Patients with Covid-19.新冠肺炎住院患者使用羟氯喹的情况
N Engl J Med. 2021 Mar 4;384(9):881-882. doi: 10.1056/NEJMc2035374. Epub 2021 Feb 10.
2
Pattern of SARS-CoV-2 infection among dependant elderly residents living in long-term care facilities in Marseille, France, March-June 2020.2020 年 3 月至 6 月，法国马赛长期护理机构中依赖他人生活的老年居民中感染 SARS-CoV-2 的模式。
Int J Antimicrob Agents. 2020 Dec;56(6):106219. doi: 10.1016/j.ijantimicag.2020.106219. Epub 2020 Nov 13.
3
Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19.羟氯喹治疗 COVID-19 住院患者的疗效。
N Engl J Med. 2020 Nov 19;383(21):2030-2040. doi: 10.1056/NEJMoa2022926. Epub 2020 Oct 8.
4
Effect of hydroxychloroquine with or without azithromycin on the mortality of coronavirus disease 2019 (COVID-19) patients: a systematic review and meta-analysis.羟氯喹联合或不联合阿奇霉素对 COVID-19 患者死亡率的影响：系统评价和荟萃分析。
Clin Microbiol Infect. 2021 Jan;27(1):19-27. doi: 10.1016/j.cmi.2020.08.022. Epub 2020 Aug 26.
5
Outcomes of Hydroxychloroquine Usage in United States Veterans Hospitalized with COVID-19.羟氯喹在美国 COVID-19 住院患者中的使用效果。
Med. 2020 Dec 18;1(1):114-127.e3. doi: 10.1016/j.medj.2020.06.001. Epub 2020 Jun 5.
6
The Pharmacokinetic and Pharmacodynamic Properties of Hydroxychloroquine and Dose Selection for COVID-19: Putting the Cart Before the Horse.羟氯喹的药代动力学和药效学特性以及COVID-19的剂量选择：本末倒置。
Infect Dis Ther. 2020 Sep;9(3):561-572. doi: 10.1007/s40121-020-00325-2. Epub 2020 Aug 1.
7
Beyond Anti-viral Effects of Chloroquine/Hydroxychloroquine.除了氯喹/羟氯喹的抗病毒作用之外。
Front Immunol. 2020 Jul 2;11:1409. doi: 10.3389/fimmu.2020.01409. eCollection 2020.
8
Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial.高剂量与低剂量磷酸氯喹作为辅助治疗对住院的严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染患者的影响：一项随机临床试验。
JAMA Netw Open. 2020 Apr 24;3(4):e208857. doi: 10.1001/jamanetworkopen.2020.8857.

Timing and dosage may be the key in the realisation of hydroxychloroquine + azithromycin treatment benefit in Covid-19 elderly patients.

作者信息

Lacout Alexis, Lounnas Valere, Perronne Christian

机构信息

Centre de diagnostic, ELSAN, Centre médico-chirurgical, Aurillac France.

EMBL Heidelberg Alumni, Heidelberg, Germany.

出版信息

Int J Antimicrob Agents. 2021 Apr;57(4):106314. doi: 10.1016/j.ijantimicag.2021.106314. Epub 2021 Mar 17.

DOI:10.1016/j.ijantimicag.2021.106314
PMID:33722657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7967398/
Abstract
摘要