Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Israel.
Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Israel.
Autoimmun Rev. 2021 May;20(5):102795. doi: 10.1016/j.autrev.2021.102795. Epub 2021 Mar 13.
This review aims to assess the current and past literature for efficacious non-invasive diagnostic markers for earlier detection of endometriosis. We briefly discussed the associations of endometriosis with other autoimmune diseases (AID), as well as the broad changes that occur within the immune system. Specifically, we focused on the usage of various autoantibodies as a potential non-invasive diagnostic tool. Autoantibodies have been noted in the literature since the 1980s and their usage could possibly reduce the delay of an endometriosis diagnosis. Our search concluded that various anti endometrial antibodies may offer useful diagnostic tools. Anti-SLP2, anti-TMOD3, anti-TPM3, and anti-PDIK1L are particularly useful for early diagnosis in minimal to mild endometriosis. Anti-alpha enolase could also be used but yields results similar to CA125. Other non anti endometrial antibodies like anti-IMP1, anti-CA, aCL, anti-STX5 may be used as additional non-invasive diagnostic tools. Anti-TPO may be beneficial in patients in endometriosis patients with concurrent polycystic ovaries syndrome (PCOS). As the pathogenesis of endometriosis continues to reveal itself, more autoantibodies are being discovered and they may offer useful non-invasive tools for the early diagnosis of endometriosis.
这篇综述旨在评估当前和过去有关内异症早期诊断的有效非侵入性诊断标志物的文献。我们简要讨论了内异症与其他自身免疫性疾病（AID）的关联，以及免疫系统内发生的广泛变化。具体而言，我们专注于各种自身抗体作为潜在非侵入性诊断工具的使用。自 20 世纪 80 年代以来，文献中就已经注意到了自身抗体的存在，它们的使用可能会减少内异症诊断的延迟。我们的研究结果表明，各种抗子宫内膜抗体可能提供有用的诊断工具。抗 SLP2、抗 TMOD3、抗 TPM3 和抗 PDIK1L 对轻度至轻度内异症的早期诊断特别有用。抗α烯醇化酶也可用于诊断，但结果与 CA125 相似。其他非抗子宫内膜抗体，如抗 IMP1、抗 CA、抗 aCL、抗 STX5，可作为额外的非侵入性诊断工具。抗 TPO 可能对同时患有多囊卵巢综合征（PCOS）的内异症患者有益。随着内异症发病机制的不断揭示，越来越多的自身抗体被发现，它们可能为内异症的早期诊断提供有用的非侵入性工具。
