The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Antimicrob Agents Chemother. 2021 May 18;65(6). doi: 10.1128/AAC.02343-20.
We evaluated the activity of manogepix against and species complex (FOSC and FSSC, respectively) isolates per CLSI document M38 broth microdilution methods. Manogepix demonstrated activity against both FOSC (MEC [minimum effective concentration] range, ≤0.015 to 0.03 μg/ml; MIC range, ≤0.015 to 0.125 μg/ml) and FSSC (MEC, ≤0.015 μg/ml; MIC, ≤0.015 to 0.25 μg/ml). Amphotericin B was also active (MIC, 0.25 to 4 μg/ml), whereas the triazoles (MIC, 1 to >16 μg/ml) and micafungin (MEC, ≥8 μg/ml) had limited activity.
我们按照 CLSI 文件 M38 肉汤微量稀释法评估了 manogepix 对真菌属（FOSC 和 FSSC，分别）复合体分离株的活性。manogepix 对 FOSC（MEC [最低有效浓度]范围，≤0.015 至 0.03μg/ml；MIC 范围，≤0.015 至 0.125μg/ml）和 FSSC（MEC，≤0.015μg/ml；MIC，≤0.015 至 0.25μg/ml）均具有活性。两性霉素 B 也具有活性（MIC，0.25 至 4μg/ml），而三唑类（MIC，1 至>16μg/ml）和米卡芬净（MEC，≥8μg/ml）的活性有限。
