School of Biotechnology, Shri Mata Vaishno Devi University, Katra, Jammu and Kashmir, India.
Department of Biotechnology, Kashmir University, Srinagar, Jammu and Kashmir, India.
J Cancer Res Ther. 2021 Jan-Mar;17(1):46-50. doi: 10.4103/jcrt.JCRT_844_20.
In this study, we evaluated the association of rs6964823 of the Ikaros Family Zinc Finger 1 (IKZF1) gene with the risk of colorectal cancer (CRC) within the population of Jammu and Kashmir (J and K).
The variant rs6964823 of the IKZF1 gene was genotyped using the TaqMan allele discrimination assay for 578 individuals (182 CRC cases and 396 healthy controls). The association of single-nucleotide polymorphisms with the disease was evaluated using logistic regression.
It was observed that the variant rs6964823 (IKZF1) showed a significant association with an adjusted allelic odds ratio (OR) of 1.74 (1.34-2.27) at 95% confidence interval (CI), P ≤ 0.05. The dominant model (AA + AG vs. GG) was also applied, where the adjusted OR was 3.096 (2.011-4.76) at 95% CI, P > 0.05.
It was found that the variant rs6964823 of the IKZF1 gene is associated with a higher risk of CRC within the population of J and K.
在这项研究中，我们评估了 Ikaros 家族锌指蛋白 1（IKZF1）基因的 rs6964823 变体与查谟和克什米尔（J 和 K）人群中结直肠癌（CRC）风险之间的关联。
使用 TaqMan 等位基因鉴别检测对 578 个人（182 例 CRC 病例和 396 例健康对照）进行了 IKZF1 基因变异 rs6964823 的基因分型。使用逻辑回归评估单核苷酸多态性与疾病的关联。
观察到变体 rs6964823（IKZF1）与调整后的等位基因比值比（OR）具有显著相关性，95%置信区间（CI）为 1.74（1.34-2.27），P≤0.05。还应用了显性模型（AA+AG vs. GG），其中调整后的 OR 为 95%CI 的 3.096（2.011-4.76），P>0.05。
发现 IKZF1 基因的变体 rs6964823 与 J 和 K 人群中 CRC 的较高风险相关。
