Cellular and Molecular Research Centre, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India.
Br J Cancer. 2021 May;124(10):1621-1622. doi: 10.1038/s41416-021-01314-z. Epub 2021 Mar 15.
Dysregulation of N6-methyladenosine (m6A) modification is associated with cancer development and progression. The m6A modification plays a crucial role in autophagy regulation precipitating anti-cancer drug resistance. In line with this fact, this commentary discusses m6A modification interfering with autophagy machinery as a major contributing factor for drug resistance in cancer.
N6-甲基腺苷（m6A）修饰的失调与癌症的发生和发展有关。m6A 修饰在自噬调控中起着至关重要的作用，导致了抗癌药物耐药性。基于这一事实，本评论讨论了 m6A 修饰干扰自噬机制作为癌症耐药性的一个主要因素。
