Gottschalk Gunnar, Knox Konstance, Roy Avik
Technology Innovation Center, 10437 W Innovation Drive, Suite # 325, Wauwatosa, WI 53226, United States of America.
Coppe Laboratories, W229N1870 Westwood Dr, Waukesha, WI 53186, United States of America.
Gene Rep. 2021 Jun;23:101077. doi: 10.1016/j.genrep.2021.101077. Epub 2021 Mar 11.
Upregulation of Angiotensin Converting Enzyme-2 (ACE2) was frequently observed in patients with lung cancer. Interestingly, our recent study revealed that the same ACE2 receptor was also strongly upregulated in lungs during SARS-CoV2 infection. Therefore, it is possible that the upregulated expression of ACE2 in lung tumors might increase the susceptibility to COVID-19 infection in lung cancer patients. However, the molecular mechanism for the regulation of ACE2 is known neither in lung tumors nor in COVID-19. Under this review, we attempt to identify transcription factors (TFs) in the promoter of ACE2 that promote the expression of ACE2 both in COVID-19 infection and lung cancer. This review would decipher the molecular role of ACE2 in the upscaled fatality of lung cancer patients suffering from COVID-19.
肺癌患者中经常观察到血管紧张素转换酶2（ACE2）的上调。有趣的是，我们最近的研究表明，在SARS-CoV2感染期间，肺部的同一ACE2受体也强烈上调。因此，肺肿瘤中ACE2表达上调可能会增加肺癌患者对COVID-19感染的易感性。然而，无论是在肺肿瘤还是在COVID-19中，ACE2调控的分子机制都尚不清楚。在本综述中，我们试图确定ACE2启动子中的转录因子（TFs），这些转录因子在COVID-19感染和肺癌中均促进ACE2的表达。本综述将解读ACE2在患有COVID-19的肺癌患者死亡率上升中的分子作用。
