氩激光虹膜切开术后大泡性角膜病变行 Descemet 膜撕除自动化内皮角膜移植术的长期疗效。

Long-term outcomes of Descemet stripping automated endothelial keratoplasty for bullous keratopathy after argon laser iridotomy.

机构信息

Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Takara-machi 13-1, Kanazawa, Ishikawa-ken, 920-8641, Japan.

出版信息

Jpn J Ophthalmol. 2021 Jul;65(4):454-459. doi: 10.1007/s10384-021-00832-w. Epub 2021 Mar 16.

DOI:10.1007/s10384-021-00832-w

PMID:33723686

Abstract

PURPOSE

To report the long-term outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) for bullous keratopathy secondary to argon laser iridotomy (BK-ALI).

STUDY DESIGN

Retrospective chart review.

METHODS

Forty-five eyes from 41 consecutive patients with BK-ALI who underwent DSAEK from July 2007 to December 2013 were retrospectively analyzed. Best spectacle-corrected visual acuity (BCVA), endothelial cell density (ECD), and any complications were investigated over a 10-year postoperative period.

RESULTS

The mean BCVA improved from 0.80 logMAR before DSAEK to 0.28 logMAR at 6 months after DSAEK; the mean values showed an additional slight improvement between 6 months and 10 years after the surgery (P < .01). The mean ECD decreased from 2864 cells/mm at baseline to 2269 cells/mm (20.8% loss) at 6 months post-DSAEK, and this decreasing trend continued throughout the 10 years after DSAEK (P < .01). The mean ECD was 1148 cells/mm (59.9% loss) after 5 years, and 568 cells/mm (80.2% loss) after 10 years. No graft deaths were observed throughout the 10-year period (5-year follow-up rate 60.0%, 10-year follow-up rate 20.0%).

CONCLUSIONS

The 10-year outcomes of DSAEK for BK-ALI were excellent with a high graft survival rate.

摘要

目的

报告因氩激光虹膜切开术（BK-ALI）继发大泡性角膜病变而行去表皮角膜内皮移植术（DSAEK）的长期结果。

研究设计

回顾性图表分析。

方法

回顾性分析 2007 年 7 月至 2013 年 12 月间 41 例 45 眼因 BK-ALI 行 DSAEK 的患者。术后 10 年，我们研究了最佳矫正视力（BCVA）、内皮细胞密度（ECD）和任何并发症。

结果

平均 BCVA 从 DSAEK 术前的 0.80 logMAR 提高到术后 6 个月的 0.28 logMAR；在术后 6 个月至 10 年间，平均值显示出进一步的轻微改善（P<.01）。平均 ECD 从基线的 2864 个细胞/mm 下降到 DSAEK 术后 6 个月的 2269 个细胞/mm（下降 20.8%），并且这种下降趋势一直持续到 DSAEK 术后 10 年（P<.01）。术后 5 年平均 ECD 为 1148 个细胞/mm（下降 59.9%），术后 10 年为 568 个细胞/mm（下降 80.2%）。在整个 10 年期间，没有观察到移植物死亡（5 年随访率为 60.0%，10 年随访率为 20.0%）。