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新生儿重症监护病房早产儿脓毒性休克和血流动力学监测:实时电心图在管理和治疗策略定制中的附加价值。

Neonatal Septic Shock and Hemodynamic Monitoring in Preterm Neonates in an NICU: Added Value of Electrical Cardiometry in Real-Time Tailoring of Management and Therapeutic Strategies.

机构信息

Neonatal Intensive Care Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.

出版信息

Am J Perinatol. 2022 Oct;39(13):1401-1404. doi: 10.1055/s-0041-1726123. Epub 2021 Mar 15.

Abstract

OBJECTIVE

Electrical cardiometry is an impedance-based monitoring technique that provides data on several hemodynamic parameters in a noninvasive way. There is limited information on clinical utility of the application of this technique in neonates.

STUDY DESIGN

In this study, we describe the case of a preterm neonate born at 30 weeks of gestational age who developed severe systemic infection with fluid refractory septic shock on day 2 of life.

DISCUSSION

Electrical cardiometry was used and proved very helpful in real-time guiding the choice and the dosing of the most appropriate inotrope drugs in this patient. In addition, it promptly underlined an abrupt drop of systemic vascular resistances occurring after administration of the first dose of antibiotic, thus warning the attending neonatologist to institute appropriate treatment before the clinical conditions could further worsen.

CONCLUSION

This case report suggests that electrical cardiometry could be a useful tool in assessing, monitoring, and guiding care of neonates who develop severe septic shock. We suggest that electrical cardiometry is a promising approach in the management strategies of such patients that warrants informative clinical trials.

KEY POINTS

· Electrical cardiometry was helpful in real-time decision-making.. · Electrical cardiometry reported hemodynamic perturbations before worsening of clinical conditions.. · Electrical cardiometry should be included in the management of critical patients..

摘要

目的

心电图测量是一种基于阻抗的监测技术,可无创提供多项血流动力学参数的数据。关于该技术在新生儿中的临床应用价值,目前信息有限。

研究设计

本研究描述了一例胎龄 30 周的早产儿,出生后第 2 天发生严重全身感染伴液体难治性感染性休克。

讨论

本研究中使用了心电图测量技术,事实证明该技术在实时指导选择和调整最合适的正性肌力药物方面非常有帮助。此外,它还及时提示在使用首剂抗生素后出现的全身血管阻力突然下降,从而提醒主治新生儿科医生在临床病情进一步恶化之前采取适当的治疗措施。

结论

本病例报告提示心电图测量技术可用于评估、监测和指导发生严重感染性休克的新生儿的治疗。我们建议心电图测量技术是此类患者管理策略中很有前途的方法,值得开展信息丰富的临床试验。

关键点

·心电图测量技术有助于实时决策。·心电图测量技术在临床状况恶化之前报告血流动力学变化。·应将心电图测量技术纳入危重症患者的管理中。

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