Bisceglie Valeria, Loi Barbara, Vitelli Ottavio, Proto Alice, Ferrari Maria Elena, Vivalda Laura, Di Nardo Matteo, Martinelli Stefano, De Luca Daniele
Division of Pediatrics and Neonatal Critical Care, "A. Béclère" Medical Center, Paris-Saclay University Hospitals, APHP, Paris, France.
Physiopathology and Therapeutic Innovation Unit-INSERM U999, Paris-Saclay University, Paris, France.
J Perinatol. 2025 Mar;45(3):334-341. doi: 10.1038/s41372-024-02115-x. Epub 2024 Sep 17.
Scanty data are available about neonatal systemic vascular resistances (SVR). We aim to provide reference values and nomograms for neonatal SVR.
Multicenter, cross-sectional,descriptive study performed in France and Italy. Neonates with complete hemodynamic stability were enrolled. Non-invasive measurements of SVR by electrical cardiometry performed once, after the first 72 h and before the 7th day of postnatal age.
We studied 1094 neonates: SVR was correlated with gestational age (ρ = -0.55, adj-r = -0.46, p < 0.001) and birth weight (ρ = -0.59, adj-r = -0.45, p < 0.001) irrespective of newborn sex. The relationships between SVR, gestational age and birth weight were represented by power equations and SVR was decreasing with increasing age and weight. Age- and weight-based SVR nomograms had optimal goodness-of-fit (non-linear R ≥0.74). Similar results were obtained for body surface indexed-SVR.
In hemodynamically stable neonates, SVR decrease with increasing gestational age and birth weight. Specific gestational age and birth weight-based nomograms are provided for the clinical interpretation.
关于新生儿体循环血管阻力（SVR）的数据较少。我们旨在提供新生儿SVR的参考值和列线图。
在法国和意大利进行的多中心、横断面描述性研究。纳入血流动力学完全稳定的新生儿。在出生后72小时后、出生后第7天前，通过心电描记法对SVR进行一次无创测量。
我们研究了1094例新生儿：无论新生儿性别如何，SVR均与胎龄（ρ = -0.55，校正r = -0.46，p < 0.001）和出生体重（ρ = -0.59，校正r = -0.45，p < 0.001）相关。SVR、胎龄和出生体重之间的关系由幂方程表示，且SVR随年龄和体重增加而降低。基于年龄和体重的SVR列线图具有最佳拟合优度（非线性R≥0.74）。基于体表面积指数的SVR也获得了类似结果。
在血流动力学稳定的新生儿中，SVR随胎龄和出生体重增加而降低。提供了基于特定胎龄和出生体重的列线图用于临床解读。
