联体共生模型：方案、应用及展望

Yang Cui, Liu Zhi-Lan, Wang Jun, Bu Xian-Le, Wang Yan-Jiang, Xiang Yang

Institute of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China.

Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, Sichuan 610072, China.

Zool Res. 2021 May 18;42(3):253-261. doi: 10.24272/j.issn.2095-8137.2020.368.

Parabiosis is a surgical method of animal modeling with a long history. It has been widely used in medical research, particularly in the fields of aging, stem cells, neuroscience, and immunity in the past two decades. The protocols for parabiosis have been improved many times and are now widely accepted. However, researchers need to consider many details, from surgical operation to perioperative management, to reduce mortality and maintain the parabiosis union. Although parabiosis has certain inevitable limitations, it still has broad application prospects as an irreplaceable animal model in the medical research field.

联体生活是一种具有悠久历史的动物建模手术方法。在过去二十年中，它已广泛应用于医学研究，尤其是在衰老、干细胞、神经科学和免疫领域。联体生活的实验方案已经多次改进，现在已被广泛接受。然而，从手术操作到围手术期管理，研究人员需要考虑许多细节，以降低死亡率并维持联体状态。尽管联体生活有一定不可避免的局限性，但作为医学研究领域中不可替代的动物模型，它仍然具有广阔的应用前景。