Smith Jennifer R, Bolton Elizabeth R, Dwinell Melinda R
Department of Biomedical Engineering, Rat Genome Database, Medical College of Wisconsin, Milwaukee, WI, USA.
Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI, USA.
Methods Mol Biol. 2019;2018:1-41. doi: 10.1007/978-1-4939-9581-3_1.
The laboratory rat, Rattus norvegicus, has been used in biomedical research for more than 150 years, and in many cases remains the model of choice for studies of physiology, behavior, and complex human disease. This book provides detailed information on a number of methodologies that can be used in rat. This chapter gives an introduction to rat as a species and as a biomedical model, providing historical information, a brief introduction to the current state of rat research, and a perspective on the future of rat as a model for human disease.
实验大鼠，褐家鼠，已在生物医学研究中使用了150多年，并且在许多情况下仍然是生理学、行为学和复杂人类疾病研究的首选模型。本书提供了一些可用于大鼠研究的方法的详细信息。本章介绍了大鼠这一物种及其作为生物医学模型的情况，提供了历史信息、大鼠研究现状的简要介绍，以及对大鼠作为人类疾病模型未来发展的展望。
