Lenck-Santini Pierre-Pascal
56180Aix-Marseille University, INSERM, INMED, Marseille, France.
Epilepsy Curr. 2021 Mar 16;21(3):15357597211001877. doi: 10.1177/15357597211001877.
The precise coordination of neuronal activity is critical for optimal brain function. When such coordination fails, this can lead to dire consequences. In this review, I will present evidence that in epilepsy, failed coordination leads not only to seizures but also to alterations of the rhythmical patterns observed in the electroencephalogram and cognitive deficits. Restoring the dynamic coordination of epileptic networks could therefore both improve seizures and cognitive outcomes.
神经元活动的精确协调对于最佳脑功能至关重要。当这种协调失败时，可能会导致严重后果。在本综述中，我将提供证据表明，在癫痫中，协调失败不仅会导致癫痫发作，还会导致脑电图中观察到的节律模式改变和认知缺陷。因此，恢复癫痫网络的动态协调可能会改善癫痫发作和认知结果。
