齿状回苔藓细胞控制自发性惊厥发作和空间记忆。
Dentate gyrus mossy cells control spontaneous convulsive seizures and spatial memory.
作者信息
Bui Anh D, Nguyen Theresa M, Limouse Charles, Kim Hannah K, Szabo Gergely G, Felong Sylwia, Maroso Mattia, Soltesz Ivan
机构信息
Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA.
出版信息
Science. 2018 Feb 16;359(6377):787-790. doi: 10.1126/science.aan4074.
Abstract
Temporal lobe epilepsy (TLE) is characterized by debilitating, recurring seizures and an increased risk for cognitive deficits. Mossy cells (MCs) are key neurons in the hippocampal excitatory circuit, and the partial loss of MCs is a major hallmark of TLE. We investigated how MCs contribute to spontaneous ictal activity and to spatial contextual memory in a mouse model of TLE with hippocampal sclerosis, using a combination of optogenetic, electrophysiological, and behavioral approaches. In chronically epileptic mice, real-time optogenetic modulation of MCs during spontaneous hippocampal seizures controlled the progression of activity from an electrographic to convulsive seizure. Decreased MC activity is sufficient to impede encoding of spatial context, recapitulating observed cognitive deficits in chronically epileptic mice.
摘要
颞叶癫痫（TLE）的特征是反复发作使人衰弱的癫痫，以及认知缺陷风险增加。苔藓细胞（MCs）是海马兴奋性回路中的关键神经元，MCs的部分丧失是TLE的主要标志。我们使用光遗传学、电生理学和行为学方法相结合的方式，研究了在伴有海马硬化的TLE小鼠模型中，MCs如何促进自发性发作活动和空间情境记忆。在慢性癫痫小鼠中，在自发性海马癫痫发作期间对MCs进行实时光遗传学调制，可控制活动从脑电图发作进展为惊厥性发作。MCs活性降低足以阻碍空间情境的编码，重现慢性癫痫小鼠中观察到的认知缺陷。
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