Department of Clinical Laboratory, 540418The Second Hospital of Dalian Medical University, Dalian, China.
Clin Appl Thromb Hemost. 2021 Jan-Dec;27:10760296211000129. doi: 10.1177/10760296211000129.
A growing researchers have suggested that fibrin monomer (FM) plays an important role in early diagnosis of thrombotic diseases. We explored the application of FM in the diagnosis and classification of acute ischemic stroke (AIS). The differences in FM, D-dimer, and NIHSS scores between different TOAST (Trial of ORG 10172 in Acute Stroke Treatment) types were analyzed with one-way ANOVA; the correlation between FM, D-dimer and NIHSS score in patients with different TOAST classification was analyzed by Pearson linear correlation. The ROC curve was utilized to analyze the diagnostic performance. 1. FM was more effective in diagnosing patients with AIS than D-dimer. 2. The FM level in cardiogenic AIS was significantly different from that in non-cardiogenic patients ( < 0.05); the NIHSS score in cardiogenic stroke was significantly higher than in atherosclerotic and unexplained stroke group. Whereas, no statistical difference was observed in the D-dimer level between these groups ( > 0.05). 3. The correlation between FM and NIHSS scores in the cardiogenic (r = 0.3832) and atherosclerotic (r = 0.3144) groups was statistically significant. 4. FM exhibited the highest diagnostic efficacy for cardiogenic AIS; furthermore, FM combined with the NIHSS score was more conducive to the differential diagnosis of cardiogenic and non-cardiogenic AIS. FM detection contributes to the early diagnosis of AIS, and is important for the differential diagnosis of different TOAST types of AIS. Moreover, FM combined with the NIHSS score is valuable in the differential diagnosis of cardiogenic and non-cardiogenic AIS.
越来越多的研究人员表明纤维蛋白单体（FM）在血栓性疾病的早期诊断中起着重要作用。我们探讨了 FM 在急性缺血性脑卒中（AIS）的诊断和分类中的应用。采用单因素方差分析比较不同 TOAST（急性卒中治疗 ORG 10172 试验）类型患者 FM、D-二聚体和 NIHSS 评分的差异；采用 Pearson 线性相关分析不同 TOAST 分类患者 FM、D-二聚体与 NIHSS 评分的相关性。采用 ROC 曲线分析诊断效能。1. FM 诊断 AIS 患者的效果优于 D-二聚体。2. 心源性 AIS 患者的 FM 水平与非心源性患者的 FM 水平差异有统计学意义（<0.05）；心源性卒中患者的 NIHSS 评分明显高于动脉粥样硬化性和不明原因性卒中组，而心源性和非心源性卒中患者 D-二聚体水平差异无统计学意义（>0.05）。3. 心源性（r=0.3832）和动脉粥样硬化性（r=0.3144）组 FM 与 NIHSS 评分之间的相关性有统计学意义。4. FM 对心源性 AIS 的诊断效能最高；此外，FM 联合 NIHSS 评分更有利于心源性和非心源性 AIS 的鉴别诊断。FM 检测有助于 AIS 的早期诊断，对不同 TOAST 类型 AIS 的鉴别诊断具有重要意义。此外，FM 联合 NIHSS 评分在心源性和非心源性 AIS 的鉴别诊断中具有价值。
