血清CXCL9/12与急性缺血性卒中严重程度的相关性：一项回顾性观察研究
Correlations Between Serum CXCL9/12 and the Severity of Acute Ischemic Stroke, a Retrospective Observational Study.
作者信息
Han Miaomiao, Ma Bo, She Ruifang, Xing Yan, Li Xiaohong
机构信息
Department of Neurology, Jinan Central Hospital, Shandong University, Jinan City, People's Republic of China.
Encephalopathy Department, Zibo Hospital of Integrated Traditional Chinese and Western Medicine, Zibo City, People's Republic of China.
出版信息
Neuropsychiatr Dis Treat. 2023 Jan 29;19:283-292. doi: 10.2147/NDT.S391578. eCollection 2023.
PURPOSE
This retrospective observational study was conducted to determine the correlations between serum CXCL9/12 and the severity of acute ischemic stroke (AIS).
METHODS
Total 138 patients with AIS were enrolled in the study. These patients underwent Brain CT on admission and blood samples were collected. Serum CXCL9 and CXCL12 were detected by ELISA assay. The correlations of serum CXCL9/12 with AIS was analyzed based on Oxfordshire Community Stroke Project (OCSP) classification, Trial of Org 10,172 in acute stroke treatment (TOAST) classification, National Institutes of Health Stroke Score (NIHSS) score, infarct volume, and modified Rankin scale (mRS) score.
RESULTS
Compared with the controls, patients with AIS had higher levels of serum CXCL9 and CXCL12. Logistic regression analysis determined that CXCL9 and CXCL12 were independent risk factors for AIS. In addition, the increased serum CXCL9 and CXCL12 were associated with TOAST classification, NIHSS score, and infarct volume. However, serum CXCL9 and CXCL12 were not associated with functional outcomes (mRS score). CXCL9 and CXCL12 both exhibited a high diagnostic value in AIS.
CONCLUSION
Serum CXCL9 and CXCL12 were elevated in patients with AIS, closely correlated with the severity of AIS.
目的
本回顾性观察研究旨在确定血清CXCL9/12与急性缺血性卒中（AIS）严重程度之间的相关性。
方法
共纳入138例AIS患者。这些患者入院时接受脑部CT检查并采集血样。采用酶联免疫吸附测定法检测血清CXCL9和CXCL12。基于牛津郡社区卒中项目（OCSP）分类、急性卒中治疗中Org 10,172试验（TOAST）分类、美国国立卫生研究院卒中量表（NIHSS）评分、梗死体积和改良Rankin量表（mRS）评分，分析血清CXCL9/12与AIS的相关性。
结果
与对照组相比，AIS患者血清CXCL9和CXCL12水平更高。Logistic回归分析确定CXCL9和CXCL12是AIS的独立危险因素。此外，血清CXCL9和CXCL12升高与TOAST分类、NIHSS评分和梗死体积相关。然而，血清CXCL9和CXCL12与功能结局（mRS评分）无关。CXCL9和CXCL12在AIS中均表现出较高的诊断价值。
结论
AIS患者血清CXCL9和CXCL12升高，与AIS严重程度密切相关。
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