Department of Neurology, 363 Hospital, Chengdu, China. Email:
Department of Neurology, 363 Hospital, Chengdu, China.
Ann Palliat Med. 2021 Jan;10(1):148-155. doi: 10.21037/apm-20-2200. Epub 2021 Jan 11.
Acute ischemic stroke (AIS) is closely related to the level of inflammatory factors. This study aimed to explore the correlation between interleukin-6 (IL-6), interleukin-8 (IL-8), and the modified early warning score (MEWS) of AIS patients and their condition and prognosis.
The clinical data of 95 AIS patients admitted to our hospital from January 2019 to October 2019 were selected, and 91 cases were finally recruited to the study group according to the inclusion and exclusion criteria. A control group was recruited comprising 70 healthy patients. The differences in IL-6 and IL-8 levels between the 2 groups were compared. Multiple logistic regression analysis was used to analyze the independent risk factors affecting the prognosis of AIS patients. A receiver-operating characteristic (ROC) curve was used to analyze the predictive value of IL-6, IL-8, and MEWS for the poor prognosis of AIS patients.
The levels of IL-6 and IL-8 in the study group were higher than those of the control group (P<0.05). After 90 days of treatment, 69 cases in the study group allocated into the good prognosis group, and 22 were allocated into the poor prognosis group. The National Institutes of Health Stroke Scale (NIHSS) scores before thrombolysis, blood glucose before thrombolysis, systolic blood pressure 2 h after thrombolysis, IL-6, IL-8, and MEWS scores within 24 h of admission in the good prognosis group were lower than those of the poor prognosis group (P<0.05). The area under the curve (AUC) of IL-6, IL-8, MEWS, and the 3 combined curves were 0.937, 0.897, 0.839, and 0.976, respectively, and the area under the combined detection curve was the largest.
The inflammatory response and secondary brain damage after AIS are influenced by IL-6 and IL-8. Combined with the MEWS score, IL-6 and IL-8 can be used as important indicators to judge the severity of the early condition of AIS patients. The combination of these 3 indicators has high accuracy in evaluating the prognosis of patients and is worthy of clinical promotion.
急性缺血性脑卒中（AIS）与炎症因子水平密切相关。本研究旨在探讨白细胞介素-6（IL-6）、白细胞介素-8（IL-8）与 AIS 患者改良早期预警评分（MEWS）与病情及预后的相关性。
选取我院 2019 年 1 月至 10 月收治的 95 例 AIS 患者的临床资料，根据纳入排除标准，最终纳入 91 例患者进入研究组，同时选取同期健康体检者 70 例纳入对照组。比较两组患者 IL-6、IL-8 水平的差异，采用多因素 logistic 回归分析影响 AIS 患者预后的独立危险因素，绘制受试者工作特征（ROC）曲线分析 IL-6、IL-8、MEWS 对 AIS 患者不良预后的预测价值。
研究组患者 IL-6、IL-8 水平高于对照组（P<0.05）。治疗 90d 后，研究组患者中预后良好 69 例，预后不良 22 例。预后良好组患者溶栓前美国国立卫生研究院卒中量表（NIHSS）评分、溶栓前血糖、溶栓后 2h 收缩压、入院后 24hIL-6、IL-8、MEWS 评分均低于预后不良组（P<0.05）。IL-6、IL-8、MEWS 及三者联合曲线的曲线下面积（AUC）分别为 0.937、0.897、0.839、0.976，且三者联合检测曲线的 AUC 最大。
AIS 后炎症反应及继发性脑损伤与 IL-6、IL-8 有关，联合 MEWS 评分，IL-6、IL-8 可作为判断 AIS 患者早期病情严重程度的重要指标，三者联合检测对评估患者预后具有较高的准确性，值得临床推广。
