洪都拉斯寨卡病毒感染孕妇的小头畸形结局。
Microcephaly Outcomes among Zika Virus-Infected Pregnant Women in Honduras.
机构信息
1Departamento de Laboratorio Clínico, Hospital Escuela, Tegucigalpa, Honduras.
2Instituto de Enfermedades Infecciosas y Parasitología Antonio Vidal, Tegucigalpa, Honduras.
出版信息
Am J Trop Med Hyg. 2021 Mar 15;104(5):1737-1740. doi: 10.4269/ajtmh.20-1483.
The impact of Zika virus (ZIKV) infection on pregnancies shows regional variation emphasizing the importance of studies in different geographical areas. We conducted a prospective study in Tegucigalpa, Honduras, recruiting 668 pregnant women between July 20, 2016, and December 31, 2016. We performed Trioplex real-time reverse transcriptase-PCR (rRT-PCR) in 357 serum samples taken at the first prenatal visit. The presence of ZIKV was confirmed in seven pregnancies (7/357, 2.0%). Nine babies (1.6%) had microcephaly (head circumference more than two SDs below the mean), including two (0.3%) with severe microcephaly (head circumference [HC] more than three SDs below the mean). The mothers of both babies with severe microcephaly had evidence of ZIKV infection. A positive ZIKV Trioplex rRT-PCR was associated with a 33.3% (95% CI: 4.3-77.7%) risk of HC more than three SDs below the mean.
寨卡病毒（ZIKV）感染对妊娠的影响存在地域差异，这强调了在不同地理区域进行研究的重要性。我们在洪都拉斯的特古西加尔巴进行了一项前瞻性研究，于 2016 年 7 月 20 日至 12 月 31 日期间招募了 668 名孕妇。我们对 357 份首次产前检查时采集的血清样本进行了三联实时逆转录聚合酶链反应（rRT-PCR）检测。在 7 例妊娠中（7/357，2.0%）确认存在寨卡病毒。9 名婴儿（1.6%）患有小头畸形（头围低于平均值两个标准差以上），其中 2 名（0.3%）患有严重小头畸形（头围低于平均值三个标准差以上）。这两名患有严重小头畸形婴儿的母亲均有寨卡病毒感染的证据。三联 rRT-PCR 寨卡病毒阳性与头围低于平均值三个标准差以上的风险增加 33.3%（95%CI：4.3-77.7%）相关。
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