Nakamura Zev M, Nash Rebekah P, Laughon Sarah L, Rosenstein Donald L
Department of Psychiatry, University of North Carolina at Chapel Hill, 101 Manning Drive, Campus Box #7160, Chapel Hill, NC, 27599, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Curr Psychiatry Rep. 2021 Mar 16;23(5):25. doi: 10.1007/s11920-021-01237-9.
To describe the presentation, etiologies, and suggested management of post-acute COVID-19 neuropsychiatric symptoms.
Over 30% of patients hospitalized with COVID-19 may exhibit cognitive impairment, depression, and anxiety that persist for months after discharge. These symptoms are even more common in patients who required intensive care for severe effects of the virus. In addition to the pandemic-related psychological stress, multiple biological mechanisms have been proposed to understand the neuropsychiatric symptoms observed with COVID-19. Given limited research regarding effective interventions, we recommend pharmacologic and behavioral strategies with established evidence in other medically-ill populations. Long-term, neuropsychiatric complications of COVID-19 are common and consequential. Because these are likely to co-occur with other medical problems, patients recovering from COVID-19 are best managed in clinics with highly coordinated care across disciplines and medical specialties. Future research is needed to inform appropriate interventions.
描述急性 COVID-19 后神经精神症状的表现、病因及建议的管理方法。
超过 30% 的 COVID-19 住院患者可能出现认知障碍、抑郁和焦虑，这些症状在出院后会持续数月。这些症状在因病毒严重影响而需要重症监护的患者中更为常见。除了与大流行相关的心理压力外，还提出了多种生物学机制来解释 COVID-19 中观察到的神经精神症状。鉴于关于有效干预措施的研究有限，我们建议采用在其他患病群体中有确凿证据的药物和行为策略。长期来看，COVID-19 的神经精神并发症很常见且后果严重。由于这些并发症可能与其他医疗问题同时出现，因此从 COVID-19 中康复的患者最好在跨学科和医学专科高度协调护理的诊所中接受管理。需要未来的研究来为适当的干预措施提供依据。
