V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
Perspectiva Research-and-Production Company, Novosibirsk, Russia.
Bull Exp Biol Med. 2021 Feb;170(4):544-549. doi: 10.1007/s10517-021-05103-9. Epub 2021 Mar 16.
Mesenchymal stem cells (MSC), like macrophages, can be polarized in vitro. In particular, activation of type 4 Toll-like receptor in MSC leads to the appearance of the so-called "proinflammatory" MSC phenotype (MSC1). We showed that secretome (conditioned media) of MSC1 can affect the wound healing processes: promote healing and modulate exudative inflammation and subsequent fibroplastic processes in the damaged area. These effects of secretomes of polarized MSC were superior to those of intact MSC.
间充质干细胞 (MSC) 与巨噬细胞一样，可以在体外极化。具体来说，MSC 中 4 型 Toll 样受体的激活导致所谓的“促炎”MSC 表型 (MSC1) 的出现。我们表明 MSC1 的分泌组（条件培养基）可以影响伤口愈合过程：促进愈合，并调节损伤区域的渗出性炎症和随后的纤维形成过程。极化 MSC 分泌组的这些作用优于完整 MSC。
