Department of Pediatric Neurology (DY) University of Health Sciences, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
Child and Adolescent Psychiatry Department University of Health Sciences, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
Epilepsy Res. 2021 May;172:106599. doi: 10.1016/j.eplepsyres.2021.106599. Epub 2021 Mar 5.
Autism spectrum disorder (ASD) is among the serious clinical pictures of early childhood, and its main symptoms are qualitative dysfunction in social interactions with impairment of verbal and nonverbal communication and limitations in interests and activities.
This study aimed to examine the clinical conditions that mediate this comorbidity, compare parental quality of life in isolated ASD and ASD with epilepsy, demonstrate the relationships between clinical and EEG findings obtained in diagnostic evaluation, and examine the results in light of the literature.
The study sample consisted of 154 ASD patients; 26 were girls (16.9 %) and 128 (83.1 %) were boys. Of the patients with epilepsy, seizures were focal in 14 patients (9.1 %), generalized in 9 patients (5.8 %), and unspecified in 1 patient (0.6 %). Intellectual ability was found to be a significant predictor of epilepsy diagnosis. Mean (SD) total scores in the Quality of Life in Autism Questionnaire were 131.84 (10.68) among mothers of children with ASD-epilepsy and 148.33 (14.03) among mothers of children with ASD alone (P < .001).
Many psychiatric and medical conditions can co-occur with ASD. Determining the prognostic criteria for ASD is of great importance in coordinating lifelong autism rehabilitation. Improving autism-specific symptoms will benefit children with ASD as well as help mitigate parental anxiety.
自闭症谱系障碍（ASD）是儿童早期的严重临床病症之一，其主要症状是社交互动中的定性功能障碍，言语和非言语沟通受损，以及兴趣和活动受限。
本研究旨在检查这种共病的临床情况，比较孤立性 ASD 和 ASD 伴癫痫患者的父母生活质量，展示诊断评估中获得的临床和 EEG 发现之间的关系，并根据文献检查结果。
研究样本包括 154 名 ASD 患者；26 名女孩（16.9%）和 128 名男孩（83.1%）。癫痫患者中，14 名（9.1%）为局灶性癫痫发作，9 名（5.8%）为全面性癫痫发作，1 名（0.6%）为未明确的癫痫发作。智力能力被发现是癫痫诊断的一个显著预测因素。患有 ASD-癫痫儿童的母亲的自闭症生活质量问卷总分为 131.84（10.68），患有 ASD 儿童的母亲的总分为 148.33（14.03）（P<.001）。
许多精神和医学病症都可能与 ASD 同时发生。确定 ASD 的预后标准对于协调终身自闭症康复非常重要。改善自闭症特异性症状将使 ASD 儿童受益，并有助于减轻父母的焦虑。
